溴甲酚绿法测定盐酸美金刚缓释胶囊的释放度

发布时间：2018-06-18 23:10

本文选题：盐酸美金刚缓释胶囊 + 酸性染料比色法　；参考：《北京化工大学学报(自然科学版)》2015年04期

【摘要】：建立了一种简便灵敏的用于测定盐酸美金刚缓释胶囊释放度的分析方法。采用溶剂萃取酸性染料比色法来测定盐酸美金刚缓释胶囊的释放度,染色剂选用溴甲酚绿(BCG),萃取剂为氯仿,通过改变水相p H、BCG试液用量、反应时间等条件对比色法的测定条件进行优化。结果显示,当水相p H=4.0、溴甲酚绿试液用量为4 m L时,本方法在0.3~12μg/m L质量浓度范围内具有较高的灵敏度和重复性,标准曲线为A=0.05347ρ+0.09001,r=0.9991(n=6);盐酸美金刚平均回收率为100.13%,相对标准偏差为1.86%(n=9)。
[Abstract]:A simple and sensitive method was developed for the determination of the release rate of the sustained release capsule. The release of methadone hydrochloride sustained-release capsules was determined by solvent extraction with acid dye colorimetry. Bromocresol green and chloroform were used as chromatin, and the amount of aqueous phase pHH BCG test solution was changed. Reaction time and other conditions were optimized by contrast colorimetric method. The results show that the method has high sensitivity and reproducibility in the range of 0.3 ~ 12 渭 g / mL mass concentration when the water phase pH is 4.0 and the amount of bromocresol green test solution is 4 mL. The standard curve is A ~ (0.05347) 蟻 0.09001 ~ (0.9991) N ~ (6), and the average recovery of methadone hydrochloride is 100.1313 and the relative standard deviation is 1.86%.
【作者单位】：北京化工大学生命科学与技术学院;
【分类号】：R927

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