聚乳酸-羟基乙酸纳米粒及其修饰应用

发布时间：2018-06-19 08:14

本文选题：聚乳酸-羟基乙酸 + 纳米粒　；参考：《中国药学杂志》2015年16期

【摘要】：笔者就聚乳酸-羟基乙酸(PLGA)纳米粒及其修饰手段和应用情况进行综述。根据国外文献报道,对近年来聚乳酸-羟基乙酸纳米粒的制备及其修饰作用和应用的研究进行分析和归纳。聚乳酸-羟基乙酸是缓控释可生物降解微粒制备中应用最多的载体材料之一。本篇综述重点关注聚乳酸-羟基乙酸纳米粒的制备及修饰。制备方法主要包括乳化法、界面沉积法、自乳化溶剂扩散法、溶剂注入法以及超临界流体抗溶剂法。修饰方法主要为共价交联、静电吸附和疏水作用力。修饰的目的主要可以应用于优化包囊参数、调节释放、提高细胞摄取和靶向特定的组织或细胞。
[Abstract]:In this paper, polylactic acid-glycolic acid (PLGA) nanoparticles and their modification methods and applications are reviewed. The preparation, modification and application of poly (lactic acid-glycolic acid) nanoparticles in recent years were analyzed and summarized. Poly (lactic acid-glycolic acid) is one of the most widely used carrier materials in the preparation of controlled release biodegradable particles. This review focuses on the preparation and modification of poly (lactic acid)-glycolic acid nanoparticles. The preparation methods include emulsification, interfacial deposition, self-emulsifying solvent diffusion, solvent injection and supercritical fluid antisolvent. The modification methods are covalent crosslinking, electrostatic adsorption and hydrophobic force. The aim of modification is to optimize the parameters of cyst, regulate release, increase cell uptake and target specific tissues or cells.
【作者单位】：浙江大学医学院;浙江大学医学院附属第二医院;浙江工业大学药学院;浙江大学医学院附属妇产科医院;
【基金】：国家自然科学基金资助项目(81173000) 浙江省自然科学基金资助项目(LY14H300005)
【分类号】：R943

【共引文献】