基于微气泡的超声分子影像探针及其研究进展

发布时间：2018-06-20 03:30

本文选题：分子影像探针 + 超声造影剂　；参考：《南京医科大学学报(自然科学版)》2017年02期

【摘要】：微气泡是超声成像的传统造影剂,从而也成为超声分子成像中最重要的一类探针载体,多模态、多功能、智能化是微气泡类分子探针的发展趋势。近年来一批设计新颖、功能多样的微气泡类分子探针陆续出现,文章在阐述传统微气泡分子探针发展状况的基础上,对融合多种成像方式的多模态微气泡分子探针、诊疗一体化的多功能微气泡分子探针、由特殊病理环境触发的刺激响应型超声分子探针及组织穿透力更强的纳米尺度超声分子探针,在设计思路及研究现状等方面进行了综述。
[Abstract]:Microbubble is the traditional contrast agent for ultrasonic imaging, and thus becomes the most important kind of probe carrier in ultrasonic molecular imaging. Multi-mode, multi-function, intelligence is the development trend of microbubble molecular probe. In recent years, a batch of microbubble molecular probes with novel design and various functions have appeared one after another. Based on the development of traditional microbubble molecular probes, the multimodal microbubble molecular probes with multiple imaging methods have been studied in this paper. The multifunctional microbubble molecular probe, the stimulus-responsive molecular probe triggered by the special pathological environment and the nanoscale ultrasonic molecular probe with stronger tissue penetration are reviewed in this paper.
【作者单位】：东南大学生物电子学国家重点实验室江苏省生物材料与器件重点实验室生物科学与医学工程学院;南京医科大学基础医学院生物医学工程系;
【分类号】：R981

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