抗癌肽研究进展

发布时间：2018-06-21 03:31

本文选题：抗癌肽 + 抗癌肽来源　；参考：《生物技术通报》2017年11期

【摘要】：随着全球癌症患病比例的逐年增加,癌症已经成为全球死亡的主要原因和重大的公共卫生问题。抗癌肽能破坏肿瘤细胞膜结构或抑制癌细胞增殖和迁移以及肿瘤血管的形成,几乎不表现溶血性且对正常的人体细胞基本无损伤等优点,已经成为抗肿瘤新药研究的一大热点。抗癌肽主要来源可分为4类:抗菌肽类如牛乳铁蛋白肽(Lfcin B)、天蚕素等,对细菌等微生物具有广谱高效的抑制活性,同时能够抑制多种癌细胞的增殖和生长,诱导癌细胞凋亡;多肽激素类如心房利钠肽(ANP)以及在ANP形成过程中的其他一些多肽,在临床上具有增加血管通透性、降压、利钠、利尿、舒张血管平滑肌、调节水盐平衡和抑制细胞增殖等作用,最近研究发现它们可以直接杀死肿瘤细胞或强力抑制癌细胞DNA的合成,从而抑制癌细胞的生长;多肽毒素类如蜂毒、蛇毒、蝎毒等毒性较强的生物毒素,对多种肿瘤均有抑制作用;内皮抑制素可以抑制肿瘤血管的生成抑制癌细胞的生长和转移。抗癌肽主要通过诱导细胞凋亡、破坏细胞的膜结构,改变细胞周围或细胞内p H以及增强免疫应答等多种机制来抑制癌细胞增殖。综述抗癌肽的来源、抑癌机理,并对抗癌肽的应用前景进行分析,旨为抗癌肽的深入研究和开发应用提供参考。
[Abstract]:With the increasing incidence of cancer worldwide, cancer has become a major cause of death and a major public health problem. Anticancer peptides can destroy the structure of tumor cell membrane or inhibit the proliferation and migration of cancer cells, as well as the formation of tumor blood vessels, almost no hemolysis and no damage to normal human cells, which has become a hot spot in the research of new anti-tumor drugs. The main sources of anticancer peptides can be divided into four categories: antimicrobial peptides, such as lactoferrin Bu, daponin, have broad-spectrum and high efficiency inhibitory activity against bacteria and other microorganisms, and can inhibit the proliferation and growth of many kinds of cancer cells and induce apoptosis of cancer cells; Peptide hormones such as atrial natriuretic peptide (ANPP) and other peptides in the formation of ANP have the effects of increasing vascular permeability, lowering blood pressure, natriuretic, diuretic, relaxing vascular smooth muscle, regulating water and salt balance and inhibiting cell proliferation, etc. Recent studies have found that they can directly kill tumor cells or strongly inhibit the synthesis of DNA from cancer cells, thereby inhibiting the growth of cancer cells; polypeptide toxins such as bee venom, snake venom, scorpion venom and other highly toxic biotoxins, Endothelin inhibits the angiogenesis of tumor and inhibits the growth and metastasis of cancer cells. Anticancer peptides inhibit the proliferation of cancer cells by inducing cell apoptosis, destroying cell membrane structure, changing pH around or within cells and enhancing immune response. The origin and mechanism of anticancer peptides are reviewed, and the application prospect of anticancer peptides is analyzed in order to provide reference for further research and development of anticancer peptides.
【作者单位】：武汉生物工程学院药学院;湖北工业大学生物工程与食品学院发酵工程教育部重点实验室;华南农业大学生命科学学院;
【基金】：国家自然科学基金青年基金项目(31302148) 湖北省自然科学基金(面上项目) 湖北省教育厅科研项目(B2016302)
【分类号】：R979.1

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