多糖-药物轭合物的研究与展望

发布时间：2018-06-22 17:22

本文选题：天然多糖 + 多糖-药物轭合物　；参考：《生物化学与生物物理进展》2017年04期

【摘要】：多糖类物质作为赋形剂在药物制剂中已被广泛使用,多糖结构中包含了多种活性基团如羟基、羧基、氨基等,具有良好的亲水性、生物可降解性以及生物安全性,使其在聚合物-药物轭合物的构建中成为理想的载体材料.目前天然的多糖大分子及其衍生物作为药物载体的研究方兴未艾,以多糖为载体的聚合物-药物轭合物在定位或靶向给药、组织工程、生物黏附等领域也备受关注.本文以天然多糖-药物轭合物的研究现状为切入点,总结归纳了多糖-药物轭合物的设计与构建途径,介绍了其在药物传递中的应用,讨论并分析了多糖在轭合物体系中的角色和发挥的作用,对以多糖为载体的聚合物-药物轭合物发展的方向予以了讨论.
[Abstract]:Polysaccharides, as excipients, have been widely used in pharmaceutical preparations. Polysaccharides contain many active groups such as hydroxyl, carboxyl, amino, etc. They have good hydrophilicity, biodegradability and biological safety. It makes it an ideal carrier material in the construction of polymer-drug conjugate. At present, the studies of natural polysaccharide macromolecules and their derivatives as drug carriers are in the ascendant. Polysaccharide as the carrier of polymer-drug conjugation in the field of targeting or targeting drug delivery, tissue engineering, biological adhesion and other fields have attracted much attention. In this paper, the design and construction of natural polysaccharide-drug conjugate were summarized, and its application in drug delivery was introduced. The roles and functions of polysaccharides in the conjugate system are discussed and the development direction of polymer-drug conjugates supported by polysaccharides is discussed.
【作者单位】：重庆大学化学化工学院;微纳系统与新材料国际联合研发中心;新型微纳器件与系统技术重点学科实验室;
【基金】：国家自然科学基金(21375156) 重庆市科委前沿基础研究重点项目(cstc2015jcyj BX0010);重庆市科委创新项目(cstc2015shmszx00014)资助~~
【分类号】：R943

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