CYP2B和CYP3A参与药物代谢的影响因素及对氯胺酮代谢的影响

发布时间：2018-06-23 06:36

本文选题：细胞色素P_() + CYPB　；参考：《中国药房》2017年25期

【摘要】：目的:为进一步研究氯胺酮在成瘾动物体内代谢动力学规律及细胞色素P_(450)活性的调控和相关性研究提供参考。方法:以"细胞色素P_(450)""性别""氯胺酮""CYP2B""CYP3A""Sex""Ketamine"等为关键词,组合查询1980-2016年在Pub Med、Elsevier、中国知网、万方、维普等数据库中的相关文献,对CYP2B和CYP3A参与药物代谢的诱导、抑制和性别等影响因素及对氯胺酮代谢的影响进行综述。结果与结论:共检索到相关文献256篇,其中有效文献62篇。CYP2B和CYP3A是重要的细胞色素P_(450),二者参与代谢了临床大多数药物,包括氯胺酮。诱导、抑制和性别差异等因素主要是通过改变细胞色素P_(450)的基因表达和蛋白表达来影响药物在动物体内代谢的。氯胺酮是一种被广泛滥用的药物,具有成瘾性和个体的耐受差异性。通过研究细胞色素P_(450)的基因表达和蛋白表达有利于指导研究氯胺酮在成瘾动物体内的特殊代谢动力学规律,以及为阐释成瘾动物体内的细胞色素P_(450)活性的调控机制和相关性研究提供理论支持。
[Abstract]:Aim: to provide a reference for further study on the regulation and correlation of Ketamine metabolism and cytochrome P450 activity in addictive animals. Methods: using "cytochrome P450", "sex", "ketamine", "CYP2B", "CYP3A", "Sex" Ketamine "as the key words, the relevant literatures in the database of Pub Meden Elsevier, China Zhiwang, Wanfang, Wiper, etc. from 1980 to 2016 were used to investigate the induction of CYP2B and CYP3A involved in drug metabolism. The influence factors such as inhibition and sex and the effect on ketamine metabolism were reviewed. Results & conclusion: a total of 256 literatures were retrieved, of which 62 were effective. CYP2B and CYP3A were important cytochrome P450. They were involved in the metabolism of most clinical drugs, including ketamine. Factors such as induction, inhibition and sex difference affect drug metabolism in animals by changing the gene expression and protein expression of cytochrome P450. Ketamine is a widely abused drug with addictive and individual tolerance. By studying the gene expression and protein expression of cytochrome P450, it is helpful to study the specific metabolic kinetics of ketamine in addictive animals. It also provides theoretical support for the study on the regulation mechanism and correlation of cytochrome P450 activity in addictive animals.
【作者单位】：达州职业技术学院;成都地奥集团天府药业股份有限公司;四川大学华西基础医学与法医学院;
【分类号】：R96

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