有限采样法监测造血干细胞移植患者的白消安血药浓度

发布时间：2018-06-23 18:56

本文选题：白消安 + 经典法　；参考：《中国药学杂志》2015年16期

【摘要】：目的建立有限采样方法(limited sampling strategy,LSS)用于估算造血干细胞移植(hematopoietic stem cell transplantation,HSCT)患者静脉滴注白消安(busulfan,Bu)后的药-时曲线面积(an area under the plasma concentration versus time curve,AUC)。方法 22例造血干细胞移植患者静脉滴注白消安后,采集若干时间点血浆样品,用LC-MS/MS测定白消安血药浓度,用经典方法计算药动学参数。另以稀疏血药浓度数据点建立多元回归数学模型,估算AUC0-6,并对模型进行验证。通过组内相关系数(intraclass correlation coefficient,ICC)和Bland-Altman(BA)分析评估经典法和有限采样方法的一致性。结果两点(C2、C5)预测的药动学参数回归模型的线性关系较好(调整的r2=0.917),平均预测误差为0.20%,均方根误差为4.48%,组内相关系数的95%置信区间为0.914~0.984,BA分析一致性界限为-0.9~8.8。与经典法评价结果一致。结论 C2、C5估算AUC0-6的有限采样法可用于白消安的临床血药浓度监测。
[Abstract]:Objective To establish a limited sampling strategy , which was used to estimate the area under the plasma concentration versus time curve ( AUC ) in patients with hematopoietic stem cell transplantation . Methods Twenty - two patients with hematopoietic stem cell transplantation were treated by intravenous drip . The plasma samples were collected and the parameters of pharmacokinetic parameters were calculated by LC - MS / MS . The correlation coefficient ( ICC ) and Bland - Altman ( BA ) were used to evaluate the consistency of classical and limited sampling methods .
【作者单位】：福建医科大学附属协和医院药学部;福建省食品药品质量检验研究院;福建医科大学附属协和医院血液科;
【基金】：福建省战略新兴技术应用资助项目(2013J01371) 福建省教育厅科研资助项目(JB11058)
【分类号】：R969.1

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