多孔淀粉泡沫改善达比加群酯的溶出速率

发布时间：2018-06-26 08:56

本文选题：多孔淀粉泡沫 + 生物降解材料　；参考：《中国药学杂志》2015年16期

【摘要】：目的制备多孔淀粉泡沫改善达比加群酯的溶解度和溶出速率。方法通过溶剂交换法制备多孔淀粉泡沫(PSF),并以多孔淀粉泡沫为载体,通过溶剂挥发法将达比加群酯(DE)载入多孔淀粉泡沫纳米孔道中。使用扫描电镜观察载体多孔淀粉泡沫的形态和结构,应用差示扫描量热法,X射线衍射法和傅里叶红外光谱法鉴别载药样品(PSF-DE)中达比加群酯的分散状态,并通过体外溶出实验考察其体外溶出度。结果结构表征证明成功制备了多孔淀粉泡沫,并且多孔淀粉泡沫纳米孔道的空间抑制效应有效抑制了达比加群酯的结晶。体外溶出实验表明,达比加群酯的溶出速率得到显著提高。结论多孔淀粉泡沫改善了水难溶性药物达比加群酯的亲水性。
[Abstract]:Objective to prepare porous starch foam to improve the solubility and dissolution rate of Darbin-group ester. Methods porous starch foam (PSF) was prepared by solvent exchange method, and was loaded into porous starch foam nano-channel by solvent volatilization method. The morphology and structure of porous starch foam were observed by scanning electron microscope (SEM). The dispersive state of Darbin-group ester in the drug loaded sample (PSF-DE) was identified by differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). The dissolution in vitro was investigated by the dissolution test in vitro. Results the structure characterization proved that the porous starch foam was successfully prepared, and the space inhibition effect of the porous starch foam nanopore effectively inhibited the crystallization of Darbine-group ester. In vitro dissolution experiments showed that the dissolution rate of Darby and group esters was significantly increased. Conclusion porous starch foam can improve the hydrophilicity of water insoluble drug Darby and group ester.
【作者单位】：辽宁医学院药学院;
【基金】：辽宁省大学生创新创业训练计划资助项目(201310160027) 校长基金-奥鸿博泽基金-医药创新专项资助项目(XZJJ20130104-07)
【分类号】：R943

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