溴吡斯的明纳米乳体外释放行为评价

发布时间：2018-06-26 20:24

本文选题：纳米乳 + 释放度　；参考：《中国医院药学杂志》2015年02期

【摘要】：目的:评价溴吡斯的明纳米乳(PNE)的体外释药行为。方法:选用油酸乙酯为油相,司盘80∶聚山梨酯80=2∶1为混合乳化剂,PEG400为助乳化剂,采用加水滴定法制备PNE,采用动态透析技术研究PNE在不同释放介质中的释药行为,高效液相法测定PB的释放度,拟合其释药模型,相似因子法比较释放曲线间的相似性。结果:PNE与PB在释放介质(0.1 mol·L-1的HCl、pH6.8、pH7.4、pH7.8的PBS)中的释放行为均符合Weibull模型,PNE在4种释放介质中的释放行为均相似,但其与PB在相同释放介质中的释放行为有显著性差异。结论:PNE改善了PB的释放行为,PNE的释放较PB显著减缓,具有一定的缓释作用。
[Abstract]:Objective: to evaluate the in vitro drug release behavior of brompiridamine nanoparticles (PNE). Methods: using ethyl oleate as oil phase, Span 80: polysorbate 802: 1 as mixed emulsifier PEG400 as co-emulsifier, water titration method was used to prepare PNE.The release behavior of PNE in different release media was studied by dynamic dialysis technique. The release degree of PB was measured by HPLC, the drug release model was fitted, and the similarity between release curves was compared by similarity factor method. Results the release behaviors of 1: PNE and PB in the release medium (pH 6.8 ~ + pH 7.4 ~ (-1) PBS) were similar to those in the same release medium, but there was a significant difference between the release behavior of PNE and PB in the same release medium. Conclusion the release behavior of PB was improved by% PNE, and the release of PNE was significantly slower than that of PB.
【作者单位】：重庆医科大学药物高校工程研究中心和生物化学与分子药理学重点实验室;重庆市食品药品检验所;
【分类号】：R943

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