酞嗪类化合物的合成及活性研究进展

发布时间：2018-06-27 15:28

本文选题：酞嗪类化合物 + 拼合原理　；参考：《中国药房》2016年07期

【摘要】：目的:为进一步研究和开发具有新颖结构和生物活性的酞嗪类化合物提供理论依据。方法:以"酞嗪""合成""生物活性""Phthalazine""Synthesis""Biological activity"为关键词,利用直接法、顺查法、追溯法等文献检索方法,组合查询2008年10月-2015年5月在美国《化学文摘》(网络版)、中国知网、万方、维普等数据库中与酞嗪化合物合成方法、生物活性研究相关的文献,对其合成的主要方法及生物活性进行综述。结果:共检索到相关文献50篇,其中有效文献26篇。酞嗪类化合物的合成常运用3种方法,即运用拼合原理将酞嗪结构与具有生物活性的三氮唑、四氮唑等结构进行拼合,从而合成酞嗪类化合物;修饰瓦他拉尼等酞嗪类先导化合物的结构合成酞嗪类化合物;运用绿色化学多组分"一锅煮"合成酞嗪类化合物。酞嗪类化合物具有抗癌、抗菌、抗炎等广泛的生物活性。结论:酞嗪类化合物是一类具有广泛生物活性的分子,对其结构进行优化,有望筛选出高效、低毒的候选药物。
[Abstract]:Objective: to provide theoretical basis for the further study and development of phthalazine compounds with novel structure and biological activity. Methods: taking "phthalazine" synthesis "biological activity", "synthesis", "biological activity" as the key word, using direct method, sequential search method, traceability method and other literature retrieval methods, a combination query was made in USA Chemical Abstract (Internet Edition) from October 2008 to May 2015, China Zhiwang, Wanfang, etc. The synthesis methods and bioactivities of phthalazine compounds in Viper database were reviewed. Results: a total of 50 articles were retrieved, of which 26 were valid. The synthesis of phthalazine compounds is usually carried out by three methods, that is, the structure of phthalazine is combined with triazole and tetrazole, which have biological activity, so that phthalazine compounds can be synthesized by combining the structure of phthalazine with bioactive triazole and tetrazolium. To modify the structure of phthalazine lead compounds such as Vataranil, to synthesize phthalazine compounds, and to synthesize phthalazine compounds by green chemical multicomponent "one pot boiling". Phthalazine compounds have a wide range of anti-cancer, antibacterial, anti-inflammatory and other biological activities. Conclusion: phthalazines are a class of molecules with a wide range of biological activities.
【作者单位】：郑州大学药学院/新药创制与药物安全性评价河南省协同创新中心;
【基金】：郑州大学全国大学生创新创业训练计划资助项目(No.2015xjxm234)
【分类号】：R914

【参考文献】