代谢酶和转运体介导的中药-西药相互作用的药动学机制研究进展

发布时间：2018-06-29 03:41

本文选题：代谢酶 + 转运体　；参考：《药学学报》2015年04期

【摘要】：随着中草药的广泛应用,中药-西药相互作用(herb-drug interaction,HDI)问题日益凸显。代谢酶和转运体是影响药物体内处置过程的重要因素,其表达和功能的改变常常引起药代动力学的变化,是药物相互作用的主要靶点。代谢酶负责药物的代谢清除,主要包括细胞色素P450超家族(CYP)、UDP-葡萄糖醛酸基转移酶(UGT)以及磺酸化酶(SULT);转运体参与药物的口服吸收、体内分布以及排泄,主要包括肠道转运体、肾脏转运体、肝脏转运体以及脑转运体等。葛根、银杏叶、人参、圣约翰草等中草药在临床上应用广泛,且常与西药联合应用,其成分与代谢酶以及转运体存在相互作用,容易产生HDI。本文综述代谢酶、转运体介导的HDI的药代动力学机制,阐述常用中草药在与西药联合应用时应注意的问题。
[Abstract]:With the wide application of Chinese herbal medicine, the problem of herb-drug interaction has become increasingly prominent. Metabolic enzymes and transporters are important factors affecting drug disposal in vivo. Changes in their expression and function often cause changes in pharmacokinetics and are the main targets of drug interactions. Metabolic enzymes are responsible for the metabolic clearance of drugs, including cytochrome P450 superfamily (CYP) UDP-glucuronyltransferase (UGT) and sulfonic acid transferase (SULT), transporters are involved in oral absorption, distribution and excretion of drugs, mainly intestinal transporters. Kidney transporter, liver transporter and brain transporter. Radix Puerariae, Ginkgo biloba, Ginseng and St. John's herbs are widely used in clinic, and they are often used in combination with western medicine. Their components interact with metabolic enzymes and transporters, so HDI is easy to be produced. In this paper, the pharmacokinetic mechanism of metabolic enzyme and transporter mediated HDI was reviewed, and the problems that should be paid attention to in the combination of Chinese herbal medicine and western medicine were discussed.
【作者单位】：大连医科大学药学院;
【基金】：国家自然科学基金资助项目(81273580,81072694)
【分类号】：R963

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