利福喷丁对大鼠IFN-γ、IL-12、溶菌酶及酸性磷酸酶活性的影响

发布时间：2018-06-30 08:55

本文选题：利福喷丁 + 大鼠　；参考：《中国抗生素杂志》2015年06期

【摘要】：目的研究利福喷丁对正常大鼠的IFN-γ、IL-12、溶菌酶及酸性磷酸酶活性的影响。方法 60只大鼠随机分为实验组和对照组,每组再随机分为喂药30d组(A组)、喂药90d组(B组)、喂药90d停喂药30天组(C组)。实验组给予利福喷丁,对照组给予0.1%羧甲基纤维素钠液。观察IFN-γ、IL-12、溶菌酶及酸性磷酸酶活性变化。结果 1与对照组比较:A组IFN-γ显著降低(P0.05),溶菌酶显著升高(P0.05);A组、B组酸性磷酸酶显著升高(P0.05)。2对照组内比较:B组、C组与A组比较,溶菌酶显著降低(P0.05),酸性磷酸酶显著升高(P0.05)。结论利福喷丁抑制大鼠细胞免疫,增强大鼠非特异性免疫。
[Abstract]:Aim to study the effects of rifampicin on the activities of IFN- 纬 -IL-12, lysozyme and acid phosphatase in normal rats. Methods Sixty rats were randomly divided into experimental group and control group. Each group was randomly divided into three groups: group A (group A), group B (group B) and group C (group C). The experimental group was given rifapentine, while the control group was given 0.1% sodium carboxymethyl cellulose solution. The activities of IL-12, lysozyme and acid phosphatase were observed. Results 1 compared with the control group, IFN- 纬 and lysozyme were significantly decreased (P0.05) and lysozyme significantly increased (P0.05) in the control group compared with the control group (P0.05). In the control group, the lysozyme was significantly lower (P0.05) and the acid phosphatase was significantly higher (P0.05) than that in the control group (P0.05). Conclusion Rifopentine inhibits the cellular immunity of rats and enhances the non-specific immunity of rats.
【作者单位】：成都市新都区人民医院呼吸内科;广东省阳江市人民医院呼吸内科;泸州医学院附属医院感染呼吸科;
【基金】：四川省卫生厅资助项目(No.090209)
【分类号】：R965

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