以多孔辅料为载体的固体分散体改善难溶性药物溶出度的研究进展

发布时间：2018-07-01 08:28

本文选题：多孔辅料 + 固体分散体　；参考：《中国药学杂志》2017年17期

【摘要】：溶解性是制约生物药剂学分类系统(BCS)Ⅱ类药物成药性与临床应用的关键。将药物制备成固体分散体是一种提高溶出度的有效方法。随着多孔辅料的不断研发与涌现,其独特的结构优势,使得其作为载体制备固体分散体成为药剂学研究的热点。基于此,笔者阐释了多孔辅料的概念与特点,总结了孔径大小、孔有序性及表面基团对释药性能的影响,介绍了以多孔辅料为载体的固体分散体的制备方法,归纳了常用的多孔辅料的分类、特点及应用,以期推动多孔辅料在难溶性药物中的应用,提高药物的生物利用度。
[Abstract]:Solubility is the key to restrict the proprietary drug properties and clinical application of Biopharmaceutical Classification system (BCS). The preparation of solid dispersions is an effective method to improve dissolution. With the continuous development and emergence of porous excipients, their unique structural advantages have made the preparation of solid dispersion as a carrier a hot topic in pharmaceutical research. Based on this, the author explained the concept and characteristics of porous excipients, summarized the effects of pore size, pore order and surface groups on drug release properties, and introduced the preparation method of solid dispersions based on porous excipients. The classification, characteristics and application of common porous excipients were summarized in order to promote the application of porous excipients in insoluble drugs and to improve the bioavailability of drugs.
【作者单位】：成都中医药大学药学院中药材标准化教育部重点实验室中药资源系统研究与开发利用省部共建国家重点实验室培育基地;江西中医药大学现代中药制剂教育部重点实验室;
【基金】：国家自然科学基金资助项目(81274098) 国家基础科学人才培养基金资助项目(J13100340-19)
【分类号】：R943

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