基于蒙特卡洛法的药品pH测量不确定度评定

发布时间：2018-07-03 04:20

  本文选题：不确定度评价 + pH测量　； 参考：《中国药学杂志》2017年08期

【摘要】：目的对药品中pH测定的不确定度进行评定。方法以葡萄糖氯化钠注射液pH测定为例,分别采用基于不确定度传播律(GUM)法和基于蒙特卡洛(MCM)法评定pH测定的不确定度,用MCM法验证GUM法评定不确定度的可靠性。结果 GUM法和MCM法得到的测量结果以及不确定度基本一致。结论 MCM法用于不确定度评定,是一个简便、可靠,且适用性更广的可选择方法。
[Abstract]:Objective to evaluate the uncertainty of pH determination in drugs. Methods the uncertainty of pH determination in glucose sodium chloride injection was evaluated by means of uncertainty propagation law (GUM) method and Monte Carlo method (MCM), and the reliability of gum method was verified by MCM method. Results the measurement results and uncertainty obtained by GUM method and MCM method were basically consistent. Conclusion MCM is a simple, reliable and more suitable method for uncertainty evaluation.
【作者单位】： 国家药典委员会;江苏省食品药品监督检验研究院;清华大学化学系;天津市药品检验所;贵州省食品药品检验所;
【分类号】：R927
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本文编号：2092371