聚乙二醇共聚物纳米载药体系研究

发布时间：2018-07-03 05:08

本文选题：生物可降解高分子纳米载体 + 抗肿瘤药物　；参考：《江西农业大学》2014年硕士论文

【摘要】：随着社会的高速发展,人们的生活压力变大,生存环境也变得恶劣,这些都造成了癌症的高发,严重威胁人类健康。在人类对抗癌症的手段中化疗是其中很重要的一部分,普通化疗药物如阿霉素、紫杉醇、顺铂等不仅体内半衰期短,生物利用度低,而且肿瘤靶向性不强无法有效聚集在病灶部位这些都导致了化疗效果不佳、毒副作用大,易产生耐药性,严重影响了病人的治疗和生活质量。为了解决这些问题,我们利用生物相容性好、生物降解的高分子材料设计制备了纳米药物输送体系对这些化疗药物进行担载和肿瘤靶向输送,同时我们还用这些高分子材料来担载造影剂,借助新进光声成像技术(MSOT)考察肿瘤模型及粒径大小对纳米药物生物分布和代谢的影响为以后的个性化治疗做些基础研究。具体如下： 1.设计合成了聚乙二醇聚谷氨酸嵌段共聚物,并在该高分子纳米载体上担载紫杉醇与阿霉素这两种抗肿瘤药形成纳米共载体系,随后考察了该纳米共载药体系的相关理化性质及体外细胞毒性,体内抑瘤活性得到了比较满意的结果。 2.利用聚乙二醇聚乳酸(PDLLA)纳米粒子担载近红外荧光染料吲哚青绿(ICG),通过改变投料比大小来制作出不同粒径的担载ICG的纳米粒子,然后借助新进的无损光声成像技术(MSOT)来观察这些不同粒径的纳米粒子在体内的代谢及聚集情况。通过本论文的一些工作,希望可以为生物可降解高分子纳米载药体系进行癌症的联合治疗及个体化治疗研究提供一些思路和基础研究。
[Abstract]:With the rapid development of society, people's living pressure and living environment become worse, which results in a high incidence of cancer and a serious threat to human health. Chemotherapy is a very important part of human anti-cancer methods. Common chemotherapy drugs, such as adriamycin, paclitaxel and cisplatin, not only have a short half-life in vivo, but also have low bioavailability. Moreover, the weak targeting of tumor can not be effectively concentrated in the focus which leads to the poor effect of chemotherapy, large toxic side effects, easy to produce drug resistance, which seriously affects the treatment and quality of life of patients. In order to solve these problems, we designed and prepared nanopharmaceutical delivery systems using biocompatible and biodegradable polymer materials to support and target these chemotherapeutic agents. At the same time, we also use these polymer materials to support contrast agents, and investigate the effects of tumor model and particle size on the biological distribution and metabolism of nanopharmaceuticals by means of new photoacoustic imaging (MSOT). The details are as follows: 1. Poly (ethylene glycol) poly (glutamic acid) block copolymers were designed and synthesized. Paclitaxel and adriamycin were supported on the polymer nano-carrier to form nano-co-loading system. Then the physicochemical properties and cytotoxicity of the nano-cocarrier system in vitro were investigated, and the results of tumor inhibition in vivo were satisfactory. 2. Using polyethylene glycol polylactic acid (PDLLA) nanoparticles loaded with near infrared fluorescent dye indocyanine green (ICG), different size ICG nanoparticles were prepared by changing the feeding ratio. Then the metabolism and aggregation of these nanoparticles with different particle sizes in vivo were observed by new nondestructive photoacoustic imaging (MSOT). Through some work in this paper, we hope to provide some ideas and basic research for the combination therapy and individualized treatment of cancer with biodegradable polymer nano-drug carrier system.
【学位授予单位】：江西农业大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R943

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