抗结核药物的血药浓度监测结果分析

发布时间：2018-07-03 16:05

本文选题：肺结核 + 血药浓度监测　；参考：《中国医院药学杂志》2015年21期

【摘要】：目的:分析抗结核药物血药浓度监测结果,指导临床合理用药。方法:对西安市结核病胸部肿瘤医院2014年1月-2014年12月住院的790例肺结核患者的抗结核药物血药浓度监测结果进行回顾性分析。结果:790例患者中有741例监测异烟肼的血药浓度,其中362例(48.9%)低于正常峰浓度,359例(48.4%)处于正常峰浓度范围内,20例(2.7%)高于正常峰浓度;503例监测了利福平的血药浓度,其中209例(41.6%)低于正常峰浓度,279例(55.4%)处于正常峰浓度范围内,15例(3.0%)高于正常峰浓度。16例异烟肼血药浓度不足的患者监测了调整给药剂量后的血药浓度(450 mg),其中12例(75%)患者达到了正常的血药浓度,平均改变值为1.86μg·ml-1(P0.01);10例利福平血药浓度不足患者监测了调整给药剂量后的血药浓度(900 mg),10例患者均达到了正常的血药浓度,平均改变值为6.05μg·ml-1(P0.01)。结论:相当一部分肺结核患者的血药浓度未达到最佳的治疗浓度,调整给药剂量后大部分患者的血药浓度都达到了正常浓度范围。因此抗结核药物血药浓度监测有助于临床进行个体化药物治疗,从而有效提高治疗效果。
[Abstract]:Objective: to analyze the results of monitoring the blood concentration of anti-tuberculosis drugs and to guide the rational use of drugs in clinic. Methods: the results of monitoring the blood concentration of antituberculotic drugs in 790 TB patients hospitalized in Xi'an Tuberculosis chest tumor Hospital from January 2014 to December 2014 were retrospectively analyzed. Results the plasma concentration of isoniazid was monitored in 741 out of 790 patients, of which 362 (48.9%) were below the normal peak concentration, 359 (48.4%) were in the range of normal peak concentration, 20 (2.7%) were higher than the normal peak concentration, 503 cases were monitored for rifampicin. Of these, 209 cases (41.6%) were below the normal peak concentration in 279 cases (55.4%) and 15 cases (3.0%) were within the normal peak concentration range. 16 patients with insufficient plasma concentration of isoniazid monitored the serum drug concentration (450 mg), 12 of them) after adjusting the dosage of isoniazid. (75%) the patient reached the normal blood drug concentration, The average change value was 1.86 渭 g ml-1 (P0.01) and 10 patients with rifampicin concentration deficiency were monitored after adjusting the dosage of rifampicin (900mg). All the 10 patients achieved normal blood drug concentration, and the average change value was 6.05 渭 g ml-1 (P0.01). Conclusion: a large number of pulmonary tuberculosis patients did not reach the optimal treatment concentration, and most of the patients reached the normal concentration range after adjusting the dosage. Therefore, monitoring the blood concentration of antituberculous drugs is helpful for individualized drug therapy, which can effectively improve the therapeutic effect.
【作者单位】：西安市结核病胸部肿瘤医院;中国人民解放军第451医院;西安市第九医院;
【基金】：西安市科技计划项目[编号:SF1208(3)]
【分类号】：R969

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