光谱法研究泮托拉唑钠与牛血清白蛋白的相互作用

发布时间：2018-07-04 11:32

  本文选题：泮托拉唑钠 + 荧光猝灭　； 参考：《华南师范大学学报(自然科学版)》2017年01期

【摘要】：在优化的实验条件下,运用荧光光谱法和紫外光谱法研究牛血清白蛋白(BSA)与泮托拉唑钠(PS)的结合作用.研究表明:PS对BSA的荧光有猝灭作用,属于静态猝灭.BSA能运载PS,是一个自发过程,其作用力类型主要为氢键和范德华力.BSA的亚螺旋域ⅢA是主要结合位置,离酪氨酸残基更近,有正协同作用.PS对BSA构象产生影响,使BSA腔内疏水环境的极性减弱.该研究对揭示药物动力学问题及后续抗菌类药物的研发提供了理论依据.
[Abstract]:The interaction of bovine serum albumin (BSA) with pam Tora sodium (PS) was studied by fluorescence and UV spectra under optimized experimental conditions. The results show that the fluorescence of BSA is quenched by: PS, which belongs to static quenching. BSA can transport PS. it is a spontaneous process. The force type is mainly hydrogen bond and van der Waals force. BSA subhelical domain 鈪，

本文编号：2095934