自制万古霉素质控血清用于血药浓度监测的可行性探讨

发布时间：2018-07-10 17:09

  本文选题：万古霉素 + 血药浓度　； 参考：《中国临床药理学杂志》2015年22期

【摘要】：目的探讨自制万古霉素质控血清在血药浓度监测中应用的可行性。方法取注射用盐酸万古霉素1.0 mg,注射用水溶解后加入血清基质液,制备质量浓度分别为10,20,30μg·m L-1的万古霉素质控血清并检测其浓度,考察方法准确性、质控样品的稳定性及临床应用。结果自制低、中、高浓度的万古霉素质控血清检测结果为靶值的98.0%~101.5%,-30℃保存6个月含量变化小于2%。结论自制万古霉素质控血清操作方法简单、成本低、结果准确可靠,可以作为实验室日常质量控制。
[Abstract]:Objective to investigate the feasibility of using self-made vancomycin quality control serum in monitoring blood concentration. Methods Vancomycin hydrochloride 1.0 mg for injection was used to prepare vancomycin quality control serum with mass concentration of 10 ~ 2030 渭 g / m ~ (-1), and the accuracy of the method was investigated, and vancomycin hydrochloride was added into serum matrix solution after dissolution with water for injection. Stability and clinical application of quality control samples. Results the results of low, medium and high concentration vancomycin quality control serum were 98.0% of the target value. The content of vancomycin was stored at 101.5 鈩，

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