药物不良反应知识库的建设以及统计分析

发布时间：2018-07-16 23:22

【摘要】：目的:建立一个药物与不良反应对应关系的知识库,为药物不良反应的监测以及药物不良反应研究提供一个在线资源。方法:首先通过网络爬虫从互联网获取中文的药品说明书数据,然后通过自然语言处理的方法自动从药品说明书中提取相应的不良反应,并构建相应的知识库来存储药品与不良反应的关系,最后对该知识库药品以及药品的分类进行了不良反应的统计分析。结果:建立了一个由3 683个药品和39 583个药品与不良反应关系组成的知识库,统计表明76.6%的药物有明确不良反应,其中94.5%的药物都有多于1个的不良反应;给出了不良反应最多的10种药品以及最常见的不良反应;通过对不良反应最多的100个药物的ATC分类统计显示其中多数属于抗感染药物、心血管药物和抗肿瘤药及免疫制剂三类。结论:搭建了该药物不良反应知识库网站提供免费在线查询和下载http://www.cktp.org:8006/Display/ADE,可以服务于临床药物不良反应监测和相关的不良反应研究。
[Abstract]:Aim: to establish a knowledge base of the relationship between drug and adverse drug reactions, and to provide an online resource for the monitoring of adverse drug reactions and the research of adverse drug reactions. Methods: first, the Chinese drug instruction data were obtained from the Internet by web crawler, and then the adverse reactions were automatically extracted from the drug instructions by natural language processing. A knowledge base was constructed to store the relationship between drugs and adverse reactions. Finally, the statistical analysis of adverse reactions was carried out on the knowledge base of drugs and their classification. Results: a knowledge base composed of 3 683 drugs and 39 583 drugs was established. The statistics showed that 76. 6% of the drugs had definite adverse reactions, and 94. 5% of the drugs had more than 1 side effect. Ten kinds of drugs with the most adverse reactions and the most common adverse reactions were given, and the ATC classification statistics of 100 drugs with the most adverse reactions showed that most of them were classified into three categories: antiinfective drugs, cardiovascular drugs, antitumor drugs and immune agents. Conclusion: the ADRs knowledge base provides free online query and download http: / www.cktp.org: 8006 / display / ADE, which can be used for clinical adverse drug reaction monitoring and related adverse reaction research.
【作者单位】：浙江大学生物医学工程与仪器科学学院;山西大医院药剂科;浙江大学转化医学研究院;
【基金】：国家高技术研究发展计划(863计划)(编号:2012AA02A601) 国家自然科学基金(编号:30900329)
【分类号】：R95

【共引文献】