环丙沙星诱导对铜绿假单胞菌最低抑菌浓度的影响

发布时间：2018-07-21 15:50

【摘要】：目的探讨铜绿假单胞菌经环丙沙星诱导前后对4种喹诺酮类药物最低抑菌浓度(MIC)的影响。方法以临床分离的铜绿假单胞菌为研究对象,以环丙沙星作为诱导药物,选择0.5×MIC、1×MIC、2×MIC、4×MIC 4种诱导浓度共诱导5代,用琼脂倍比稀释法测定诱导前及诱导1,3,5代菌株对环丙沙星、左氧氟沙星、氧氟沙星和莫西沙星的MIC。用重复测量方差分析方法进行统计分析。结果不考虑环丙沙星诱导浓度间的差异,不同代数间菌株对4种喹诺酮类药物MIC的差异有统计学意义(P0.05);不考虑诱导代数间的差异,不同环丙沙星诱导浓度间菌株对4种喹诺酮类药物MIC的差异有统计学意义(P0.05)。诱导代数因素与诱导浓度因素间菌株对环丙沙星、左氧氟沙星和氧氟沙星MIC有交互影响(P0.05)。结论从0.5×MIC到4×MIC环丙沙星浓度对铜绿假单胞菌均有较强的诱导作用,使喹诺酮类药物对铜绿假单胞菌的MIC有较大改变,提示临床上使用喹诺酮类药物治疗铜绿假单胞菌感染时应考虑药代动力学/药效学理论,充分优化治疗方案。
[Abstract]:Objective to investigate the effect of Pseudomonas aeruginosa on minimal inhibitory concentration (MIC) of four quinolones before and after ciprofloxacin induction. Methods the clinical isolates of Pseudomonas aeruginosa were used as the inducers. Five passages of 0.5 脳 MIC1 脳 MIC2 脳 MIC4 脳 MIC4 脳 MIC were used to induce ciprofloxacin. MICs of levofloxacin, ofloxacin and moxifloxacin. The method of repeated measurement variance analysis was used for statistical analysis. Results without considering the difference of induced concentration of ciprofloxacin, the MIC of different strains against four quinolones was statistically significant (P0.05), and the difference between induced algebras was not taken into account. The MIC of four quinolones was significantly different between different ciprofloxacin concentrations (P0.05). The MIC of ciprofloxacin, levofloxacin and ofloxacin were interacted between induced algebraic factors and induced concentration factors (P0.05). Conclusion the concentration of ciprofloxacin from 0.5 脳 MIC to 4 脳 MIC could induce Pseudomonas aeruginosa strongly, and the MIC of quinolones against Pseudomonas aeruginosa was significantly changed. It is suggested that the pharmacokinetics / pharmacodynamics theory should be taken into account in the treatment of Pseudomonas aeruginosa infection with quinolones.
【作者单位】：山西医科大学药学院;山西医科大学第二医院药学部;
【分类号】：R96

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