度米芬聚L-乳酸电纺纤维膜的制备及表征

发布时间：2018-07-24 20:47

【摘要】：目的制备阳离子表面活性剂型杀菌剂度米芬的微米纤维膜,考察不同载药量时度米芬的释放行为。方法采用均相溶液静电纺丝法制备载度米芬质量分数为1.25%、2.5%、5%的聚L-乳酸纤维,广角X-射线衍射法和差示热分析法考察度米芬在聚L-乳酸纤维表面及内部有无析出。将纤维膜置于水中释放度米芬,不同时间点取释放介质并采用高效液相色谱法测定释放介质中度米芬的含量,绘制时间-释放百分率曲线图。结果度米芬和聚L-乳酸混合溶解后能够静电纺成粗细较为均匀的纤维,纤维直径随载药量的升高而升高。纤维表面和内部无晶态度米芬析出。药物有明显的突释,在突释后至5 h呈现缓释行为,并随之进入平台期。相同时间点药物释放百分率随着载药量的增高而降低。去除突释点后,释放百分率-释放时间曲线对Freundlich方程有较高的拟合值。结论聚L-乳酸电纺纤维包裹度米芬后对后者呈现特别的释放行为,对类似结构小分子表面活性剂从电纺纤维的释放行为具有参考意义。
[Abstract]:Aim to prepare the microfiber membrane of domifen, a cationic surfactant fungicide, and to investigate the release behavior of domifen at different drug loading. Methods Poly (L-lactic acid) fibers with a mass fraction of 1.25% and 2.5% were prepared by homogeneous solution electrospinning method. Wide angle X-ray diffraction (WAXD) and differential thermal analysis (DTA) were used to investigate the precipitation of domefen on the surface and interior of poly (L-lactic acid) fibers. The fiber membrane was placed in water to release mifen. The release medium was obtained at different time points. The content of medium mifene in release medium was determined by high performance liquid chromatography (HPLC), and the time-release percentage curve was plotted. Results Dumifen and Poly (L- lactic acid) could be electrospun to form homogeneous fibers, and the diameter of fibers increased with the increase of drug loading. The surface and interior of the fibers are amorphous, and mifen is precipitated. The drug showed a sustained release behavior at 5 h after sudden release, and then entered the platform stage. At the same time, the percentage of drug release decreased with the increase of drug loading. After the sudden release point is removed, the curve of release percentage and release time has a higher fitting value to the Freundlich equation. Conclusion Poly (L- lactic acid) electrospun fibers showed a special release behavior after encapsulation of the latter, which could be used as a reference for the release behavior of similar small molecular surfactants from electrospun fibers.
【作者单位】：天津工业大学中空纤维膜材料与膜过程国家重点实验室;辽宁医学院药学院;
【基金】：国家自然科学基金资助项目(51102178) 中国博士后基金资助项目(2014M561187) 辽宁省自然科学基金资助项目(201402241)
【分类号】：R943

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