静脉注射丹酚酸A在恒河猴体内的药代动力学研究

发布时间：2018-08-01 12:26

【摘要】：丹酚酸A(salvianolic acid A,Sal A)是从丹参根中分离得到的具有多种药理活性的化合物。本文建立的恒河猴血浆中丹酚酸A的LC-MS测定方法可用于研究丹酚酸A在恒河猴体内的药代动力学特性,并考察了同时测定猴血浆中丹酚酸A、B和C的可行性。恒河猴静脉注射丹酚酸A 2.5、5和10 mg·kg-1后,2 min时的血药浓度(C2 min)分别为(28.343±6.426)、(45.679±12.301)和(113.293±24.360)mg·L-1。药时曲线下面积(AUC0 ∞)分别为(3.316±0.871)、(5.754±2.150)和(13.761±2.825)μg·L-1·h。本研究为丹酚酸A的临床前及临床研究提供了数据支持,也为丹酚酸A、B和C在猴或人体内的测定提供了参考。
[Abstract]:Salvianolic acid (A (salvianolic acid A) is a compound with many pharmacological activities isolated from the root of Salvia miltiorrhiza. The established LC-MS method for the determination of Salvianolic acid A in rhesus monkey plasma can be used to study the pharmacokinetics of Salvianolic acid A in rhesus monkey. The feasibility of simultaneous determination of Salvianolic acid A B and C in rhesus monkey plasma was investigated. The serum concentration (C2 min) of Salvianolic acid A 2.5 and 10 mg kg-1 was (28.343 卤6.426), (45.679 卤12.301) and (113.293 卤24.360) mg / L at 2 min after intravenous injection in rhesus monkey, respectively. The area under the curve (AUC0 鈭，

本文编号：2157573