雷公藤多苷片对阿托伐他汀在大鼠体内药动学的影响

发布时间：2018-08-08 12:54

【摘要】：目的研究合用雷公藤多苷片和阿托伐他汀之后,雷公藤多苷片对阿托伐他汀在大鼠体内药动学的影响。方法 12只雄性SD大鼠,随机分为A、B两组,其中A组为单独给药组,灌胃给药阿托伐他汀2 mg·kg~(-1),B组为联合用药组,灌胃给予雷公藤多苷片和阿托伐他汀,其给药剂量都为2 mg·kg~(-1)。在不同时间点取血,采用HPLC测定阿托伐他汀的血药浓度,计算并比较阿托伐他汀的药动学参数。结果与单独给药组相比,药物联用组阿托伐他汀的药动学参数发生了明显的变化,阿托伐他汀的最大血药浓度由(4.77±0.64)mg·L~(-1)上升到(7.79±0.61)mg·L~(-1),血浆曲线下面积由(12.82±3.50)mg·h·L~(-1)增加到(27.39±5.76)mg·h·L~(-1),同时达峰时间由(0.25±0.03)h延长到(0.52±0.07)h,半衰期由(2.39±0.19)h延长到(5.09±1.35)h,平均驻留时间由(2.93±0.23)h延至(4.36±0.44)h,说明阿托伐他汀的代谢可能受到了抑制。结论雷公藤多苷片和阿托伐他汀联用之后,会对阿托伐他汀的药动学产生一定程度的影响,导致达峰时间、半衰期延长,最大血药浓度增大,可能对阿托伐他汀钙的代谢具有抑制作用。本实验对雷公藤多苷片和阿托伐他汀联合用药具有一定的指导作用。
[Abstract]:Objective to study the effect of tripterygium wilfordii polyglycoside tablets and Atto vastatin tablets on the pharmacokinetics of Atto vastatin in rats. Methods Twelve male Sprague-Dawley rats were randomly divided into two groups: group A was administered alone, group B was given Atto vastatin 2 mg kg ~ (-1) by gavage, Tripterygium wilfordii polyglycoside tablets and Atto vastatin were given orally, the dosage was 2 mg kg ~ (-1). The serum concentrations of Atto vastatin were measured by HPLC at different time points, and the pharmacokinetic parameters of Atto vastatin were calculated and compared. Results the pharmacokinetic parameters of Atto vastatin in the combined drug group were significantly different from those in the single administration group. 闃挎墭浼愪粬姹，

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