毒理基因组学应用的研究进展
发布时间：2018-09-02 07:44
【摘要】：化合物安全评定一直是人们关注的焦点。随着科技的发展,毒理基因组学在化合物安全评定过程中的应用引起了研究者们的重视。毒理基因组学是利用DNA微阵列技术研究化合物作用于机体后的基因变化,将毒理基因组学技术与传统毒理学及组织病理学相结合,评价和预测化合物毒性的一门学科。近些年,研究者们在毒理基因组学方面的研究取得了较大进展。文章就毒理基因组学的应用平台及其在化合物心脏毒性、肾脏毒性、免疫毒性评定过程中的应用进行了综述,同时列出了部分国内外研究者报道的毒性标志基因。
[Abstract]:The safety assessment of compounds has always been the focus of attention. With the development of science and technology, the application of toxicology in the safety assessment of compounds has attracted much attention. Toxicogenomics is a subject that uses DNA microarray technology to study the genetic changes of compounds acting on the body, and combines toxicology genomics with traditional toxicology and histopathology to evaluate and predict the toxicity of compounds. In recent years, researchers have made great progress in toxicogenomics. In this paper, the application platform of toxicology genomics and its application in the assessment of cardiac toxicity, renal toxicity and immunotoxicity of compounds are reviewed, and the toxic marker genes reported by some researchers at home and abroad are listed.
【作者单位】： 沈阳农业大学畜牧兽医学院;沈阳出入境检验检疫局;辽宁农业职业技术学院;
【基金】：国家自然科学基金项目(31001088) 辽宁省教育厅优秀人才支持项目(LJQ2013070)
【分类号】：R99
[Abstract]:The safety assessment of compounds has always been the focus of attention. With the development of science and technology, the application of toxicology in the safety assessment of compounds has attracted much attention. Toxicogenomics is a subject that uses DNA microarray technology to study the genetic changes of compounds acting on the body, and combines toxicology genomics with traditional toxicology and histopathology to evaluate and predict the toxicity of compounds. In recent years, researchers have made great progress in toxicogenomics. In this paper, the application platform of toxicology genomics and its application in the assessment of cardiac toxicity, renal toxicity and immunotoxicity of compounds are reviewed, and the toxic marker genes reported by some researchers at home and abroad are listed.
【作者单位】： 沈阳农业大学畜牧兽医学院;沈阳出入境检验检疫局;辽宁农业职业技术学院;
【基金】：国家自然科学基金项目(31001088) 辽宁省教育厅优秀人才支持项目(LJQ2013070)
【分类号】：R99
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