自微乳化递药系统质量评价的研究进展
发布时间：2018-09-08 06:09
【摘要】：自微乳化递药系统(SMEDDS)口服后在胃肠道运动的促进下,能快速自发乳化形成粒径均一的微乳。它可增加难溶性药物的溶解度和生物利用度。对于SMEDDS的质量评价也日益受到重视。本文较全面地综述了能反映SMEDDS结构、稳定性和体外释放行为的质量评价项目及方法。此外,简要介绍了SMEDDS与固体分散、吸附、挤出滚圆等技术相结合得到的自微乳固体制剂给药系统(S-SMEDDS)及质量评价。
[Abstract]:After oral administration of (SMEDDS), a self-emulsifying drug delivery system, promoted by gastrointestinal motility, the microemulsion with uniform particle size was formed by rapid spontaneous emulsification. It can increase the solubility and bioavailability of insoluble drugs. More and more attention has been paid to the quality evaluation of SMEDDS. In this paper, the quality evaluation items and methods which can reflect the structure, stability and release behavior of SMEDDS in vitro are reviewed. In addition, the drug delivery system (S-SMEDDS) and quality evaluation of self-microemulsion solid preparation (S-SMEDDS) obtained by combining SMEDDS with solid dispersion, adsorption and extrusion roundness were briefly introduced.
【作者单位】： 中国医药工业研究总院药物制剂国家工程研究中心;
【分类号】：R943
[Abstract]:After oral administration of (SMEDDS), a self-emulsifying drug delivery system, promoted by gastrointestinal motility, the microemulsion with uniform particle size was formed by rapid spontaneous emulsification. It can increase the solubility and bioavailability of insoluble drugs. More and more attention has been paid to the quality evaluation of SMEDDS. In this paper, the quality evaluation items and methods which can reflect the structure, stability and release behavior of SMEDDS in vitro are reviewed. In addition, the drug delivery system (S-SMEDDS) and quality evaluation of self-microemulsion solid preparation (S-SMEDDS) obtained by combining SMEDDS with solid dispersion, adsorption and extrusion roundness were briefly introduced.
【作者单位】： 中国医药工业研究总院药物制剂国家工程研究中心;
【分类号】：R943
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