辅助分子伴侣对HSP90构象功能的调节及其在肿瘤中的作用

发布时间：2018-09-10 14:03

【摘要】：热休克蛋白90(heat shock protein 90,HSP90)作为一种重要的分子伴侣,参与调控众多原癌客户蛋白的折叠、装配和成熟,在肿瘤的发生发展中发挥重要作用。三磷酸腺苷(adenosine triphosphate,ATP)的结合和二磷酸腺苷(adenosine diphosphate,ADP)/ATP的交换是驱动HSP90分子伴侣构象循环的关键要素。其中一些辅助分子伴侣协助HSP90的构象循环过程,参与肿瘤恶性进展。本文对一些常见的辅助分子伴侣,如Hop、CDC37、p23、AHA1和PP5等的结构、功能及其协助HSP90参与肿瘤发生发展的过程进行综述。
[Abstract]:As an important molecular chaperone, heat shock protein 90 (HSP90) is involved in the regulation of the folding, assembly and maturation of many proto-cancer client proteins, and plays an important role in the development of cancer. The binding of adenosine triphosphate (adenosine triphosphate,ATP) and the exchange of adenosine diphosphate (adenosine diphosphate,ADP) / ATP are the key factors driving the conformational cycle of HSP90 molecular chaperones. Some of the accessory molecular chaperones assist in the conformational cycle of HSP90 and participate in the malignant progression of the tumor. In this paper, the structures, functions of some common comolecular chaperones, such as Hop,CDC37,p23,AHA1 and PP5, and the process of assisting HSP90 in tumorigenesis and development are reviewed.
【作者单位】：中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室;
【基金】：国家自然科学基金资助项目(81573466)
【分类号】：R96

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