干扰素诱导的跨膜蛋白抗病毒作用的研究进展
发布时间：2018-09-12 08:57
【摘要】：干扰素诱导的跨膜蛋白(Interferon-induced Transmembrane Proteins,IFITMs)是20世纪80年代发现的一种宿主限制因子蛋白,1996年发现该蛋白具有抗病毒作用,目前该蛋白的抗病毒作用及其作用机制已成为研究热点。研究表明IFITM能抑制多种病毒的复制,包括甲型流感病毒、人类免疫缺陷病毒-1、丙型肝炎病毒、埃博拉病毒和西尼罗病毒等。IFITM蛋白主要在病毒生命周期的早期,即病毒进入细胞质之前,发挥抑制病毒复制的作用。近来的研究表明,IFITM蛋白通过影响病毒包膜与内涵体膜的融合抑制病毒复制,但具体机制尚不明确。本文对IFITM的发现、结构、抗病毒作用以及潜在的作用机制进行了综述。
[Abstract]:Interferon-induced transmembrane protein (Interferon-induced Transmembrane Proteins,IFITMs) is a host limiting factor protein discovered in 1980s. It was found in 1996 that the protein has antiviral effect. At present, the antiviral effect and its mechanism of IFN- induced transmembrane protein have become a hot research topic. Studies have shown that IFITM inhibits the replication of a variety of viruses, including influenza A, human immunodeficiency virus -1, hepatitis C virus, Ebola virus and West Nile virus proteins, mainly in the early stages of the virus's life cycle. That is, the virus before entering the cytoplasm, play a role in inhibiting virus replication. Recent studies have shown that the IFITM protein inhibits viral replication by affecting the fusion of viral envelope and connotative membrane, but the specific mechanism remains unclear. The discovery, structure, antiviral effect and potential mechanism of IFITM are reviewed in this paper.
【作者单位】： 中国疾病预防控制中心病毒病预防控制所世界卫生组织全球流感参比和研究合作中心感染性疾病诊治协同创新中心;
【基金】：国家传染病重大专项(No.2014ZX10004002-002)
【分类号】：R96
[Abstract]:Interferon-induced transmembrane protein (Interferon-induced Transmembrane Proteins,IFITMs) is a host limiting factor protein discovered in 1980s. It was found in 1996 that the protein has antiviral effect. At present, the antiviral effect and its mechanism of IFN- induced transmembrane protein have become a hot research topic. Studies have shown that IFITM inhibits the replication of a variety of viruses, including influenza A, human immunodeficiency virus -1, hepatitis C virus, Ebola virus and West Nile virus proteins, mainly in the early stages of the virus's life cycle. That is, the virus before entering the cytoplasm, play a role in inhibiting virus replication. Recent studies have shown that the IFITM protein inhibits viral replication by affecting the fusion of viral envelope and connotative membrane, but the specific mechanism remains unclear. The discovery, structure, antiviral effect and potential mechanism of IFITM are reviewed in this paper.
【作者单位】： 中国疾病预防控制中心病毒病预防控制所世界卫生组织全球流感参比和研究合作中心感染性疾病诊治协同创新中心;
【基金】：国家传染病重大专项(No.2014ZX10004002-002)
【分类号】：R96
【相似文献】
相关期刊论文 前10条
1 ;药品[J];国外科技资料目录.医药卫生;2000年08期
2 陈家坤 ,吴中亮 ,Nichola Shahon;黄曲霉素对病毒干扰素诱导的抑制作用[J];癌变.畸变.突变;1991年02期
3 段序梅;;测定干扰素诱导酶诊断病毒性疫病[J];沂水医专学报;1982年01期
4 王全楚;HCV E_2蛋白抑制干扰素诱导的蛋白激酶活性[J];实用肝脏病杂志;2000年02期
5 李丽;闾军;肖默;罗晓岚;郑俊福;韩大康;;干扰素诱导的严重血小板减少性紫癜临床特点分析27例[J];世界华人消化杂志;2009年11期
6 回回鱼;萝卜上了街,药铺无人开[J];健康之路;2005年10期
7 黎旭,赵崇,张镜宇;人胎脑中干扰素诱导基因1-8家族cDNA的克隆[J];天津医药;1999年10期
8 陈q谇，
本文编号：2238526
本文链接：https://www.wllwen.com/yixuelunwen/yiyaoxuelunwen/2238526.html
最近更新
教材专著
