新型β-环糊精手性固定相的合成及其对贝凡洛尔的拆分
发布时间：2018-09-17 13:47
【摘要】：采用分步法合成一种新型β-环糊精衍生物并化学键合到γ-巯丙基硅胶上.在合成中的每步均对产物进行纯化及表征,并确证化合物的结构,采用湿法装柱将自制的手性固定相装填成色谱柱(250 mm×4.6 mm×5μm).在高效液相色谱中,流动相为甲醇-25 mmol/L KH_2PO_4(60/40,V/V),流速为0.5 m L/min,检测波长为259 nm,色谱柱温为25℃时,此新型β-环糊精衍生物键合硅胶手性固定相对贝凡洛尔表现出良好的分离特性.
[Abstract]:A novel 尾-cyclodextrin derivative was synthesized by a step-step method and chemically bonded to 纬-mercapto-propyl silica gel. The product was purified and characterized in every step of synthesis, and the structure of the compound was confirmed. The self-made chiral stationary phase was packed into a chromatographic column (250 mm 脳 4.6 mm 脳 5 渭 m).) by wet packing column. In high performance liquid chromatography (HPLC), the mobile phase was methanol 25 mmol/L KH_2PO_4 (60 / 40 V / V), the flow rate was 0.5 mL / min, and the detection wavelength was 25 鈩，
本文编号：2246111
[Abstract]:A novel 尾-cyclodextrin derivative was synthesized by a step-step method and chemically bonded to 纬-mercapto-propyl silica gel. The product was purified and characterized in every step of synthesis, and the structure of the compound was confirmed. The self-made chiral stationary phase was packed into a chromatographic column (250 mm 脳 4.6 mm 脳 5 渭 m).) by wet packing column. In high performance liquid chromatography (HPLC), the mobile phase was methanol 25 mmol/L KH_2PO_4 (60 / 40 V / V), the flow rate was 0.5 mL / min, and the detection wavelength was 25 鈩，
本文编号：2246111
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