线粒体通透性转换孔对细胞程序性死亡的调控机制及其靶向药物研究进展
发布时间：2018-09-18 14:27
【摘要】：线粒体通透转换特性自20世纪70年代被发现以来,在调控细胞凋亡作用方面已获得广泛认可。该特性由线粒体通透性转换孔(mPTP)介导,以线粒体内膜通透性升高,相对分子质量1.5×10~3的小分子物质自由通过线粒体膜为特征,但该通道的分子结构仍不十分清楚。探究mPTP的具体组成与调节机制,有助于提高对神经退行性疾病、心血管疾病及癌症发病机制与治疗手段的认识。本文通过对mPTP结构模型及其调控细胞程序性死亡(PCD)具体分子机制新进展的简要综述,论证了将mPTP靶向化合物作为PCD调控药物的可行性。
[Abstract]:Since the discovery of mitochondrial permeability conversion in the 1970s, it has been widely recognized in the regulation of apoptosis. This characteristic was mediated by mitochondrial permeability transition pore (mPTP), which was characterized by the increase of mitochondrial intimal permeability and the free passage of small molecular matter with relative molecular weight of 1.5 脳 10 ~ (-3) through the mitochondrial membrane, but the molecular structure of the channel was not very clear. It is helpful to understand the pathogenesis and treatment of neurodegenerative diseases, cardiovascular diseases and cancer by exploring the specific components and regulatory mechanisms of mPTP. In this paper, a brief review of the mPTP structural model and the new progress in the molecular mechanism of (PCD) regulating cell programmed death is presented, and the feasibility of using mPTP targeting compounds as PCD regulatory drugs is demonstrated.
【作者单位】： 江苏大学药学院 线粒体与神经生物学试验室;
【基金】：国家自然科学基金资助项目(81503051) 江苏省自然科学基金资助项目(BK20140574) 江苏大学高级专业人才科研启动基金项目(13JDG063);江苏大学青年骨干教师培育计划
【分类号】：R91
本文编号：2248202
[Abstract]:Since the discovery of mitochondrial permeability conversion in the 1970s, it has been widely recognized in the regulation of apoptosis. This characteristic was mediated by mitochondrial permeability transition pore (mPTP), which was characterized by the increase of mitochondrial intimal permeability and the free passage of small molecular matter with relative molecular weight of 1.5 脳 10 ~ (-3) through the mitochondrial membrane, but the molecular structure of the channel was not very clear. It is helpful to understand the pathogenesis and treatment of neurodegenerative diseases, cardiovascular diseases and cancer by exploring the specific components and regulatory mechanisms of mPTP. In this paper, a brief review of the mPTP structural model and the new progress in the molecular mechanism of (PCD) regulating cell programmed death is presented, and the feasibility of using mPTP targeting compounds as PCD regulatory drugs is demonstrated.
【作者单位】： 江苏大学药学院 线粒体与神经生物学试验室;
【基金】：国家自然科学基金资助项目(81503051) 江苏省自然科学基金资助项目(BK20140574) 江苏大学高级专业人才科研启动基金项目(13JDG063);江苏大学青年骨干教师培育计划
【分类号】：R91
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