马来酸依那普利叶酸片、氨氯地平或厄贝沙坦联合叶酸降压、降同型半胱氨酸的疗效和安全性的研究

发布时间：2018-10-05 11:51

【摘要】：目的：评价马来酸依那普利叶酸片、氨氯地平或厄贝沙坦联合叶酸用于H型高血压患者降压和降同型半胱氨酸（homocysteine，Hcy）的疗效和安全性。方法：2011年5月到2013年8月，在桂林地区，入选51-72岁H型高血压患者107例，首先服用马来酸依那普利叶酸片，若无不良反应分配到A组（52例）：马来酸依那普利+叶酸固定复方制剂（10mg/0.8mg/d），若患者出现不良反应，根据患者病情需要分配到B组（27例）：氨氯地平（5mg/d）+叶酸（0.8mg/d）或C组（28例）：厄贝沙坦（150mg/d）+叶酸（0.8mg/d），连续治疗8周。观察三组H型高血压患者的血压和同型半胱氨酸的变化。结果：1三组患者在治疗第4周、第8周收缩压、舒张压均较同组自身基线值降低（P0.05）,[收缩压：A组：（156.34±12.67）比（134.45±11.57）比（127.39±10.21）mmHg；B组：（155.81±12.78）比（146.92±15.08）比（136.85±11.65）mmHg；C组：（157.24±13.01）比（147.24±14.31）比（135.46±12.39）mmHg，均P0.05。舒张压：A组：（96.29±12.67）比（90.29±14.16）比（86.23±13.28）mmHg；B组：（97.54±12.13）比（96.52±10.23）比（88.58±14.56）mmHg；C组：（95.45±10.82）比（94.78±14.29）比（87.59±11.26）mmHg，均P0.05]，，第8周至正常水平，但A组要比B、C组降压效果好。2三组患者在治疗第4周、第8周Hcy均较同组自身基线值降低（P0.05），A、C组第8周的Hcy均较同组第4周Hcy降低（P0.05），[A组：（18.81±7.22）比（13.59±6.17）比（11.24±5.57）μmol/L；B组：（18.59±4.29）比（16.47±4.28）比（16.03±4.70）μmol/L；C组：（18.08±5.36）比（14.71±4.62）比（12.41±3.57）μmol/L]，但A组要比B、C组降同型半胱氨酸效果好。结论：马来酸依那普利叶酸片对于降低H型高血压患者近期的血压和同型半胱氨酸的效果优于氨氯地平或厄贝沙坦联合叶酸的效果。
[Abstract]:Objective: to evaluate the efficacy and safety of folic acid tablets of enalapril maleate, amlodipine or irbesartan combined with folic acid in lowering blood pressure and lowering homocysteine (homocysteine,Hcy) in patients with type H hypertension. Methods: from May 2011 to August 2013, 107 patients with H type hypertension aged 51-72 years were enrolled in Guilin area. If no adverse reactions were assigned to group A (52 cases): enalapril maleate folic acid fixed compound preparation (10mg/0.8mg/d), if the patient had adverse reactions, Group B (27 cases): amlodipine (5mg/d) folic acid (0.8mg/d) or group C (28 cases): irbesartan (150mg/d) folic acid (0.8mg/d) for 8 weeks. The changes of blood pressure and homocysteine in three groups of patients with H-type hypertension were observed. Results systolic blood pressure and diastolic blood pressure in the three groups were significantly lower than those in the same group at the 4th and 8th weeks (P0.05), [systolic blood pressure: (156.34 卤12.67) vs (134.45 卤11.57) vs (127.39 卤10.21) mmHg;B: (155.81 卤12.78) vs (146.92 卤15.08) vs (136.85 卤11.65) mmHg;C: (157.24 卤13.01) vs (147.24 卤14.31) vs (135.46 卤12.39) mmHg, P 0.05]. Diastolic blood pressure: group A: (96.29 卤12.67) vs (90.29 卤14.16) vs (86.23 卤13.28) mmHg;B: (97.54 卤12.13) vs (96.52 卤10.23) vs (88.58 卤14.56) mmHg;C: (95.45 卤10.82) vs (94.78 卤14.29) vs (87.59 卤11.26) mmHg,. 绗

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