首创性的“跟踪”药物色瑞替尼
发布时间：2018-10-21 11:47
【摘要】：正1研究背景有一种肿瘤称作间变性大细胞淋巴瘤(ALCL),是类罕见的非何杰金T细胞淋巴瘤,多发生在皮肤、骨骼、软组织和多种脏器中,这种全身性肿瘤的发生原因,大多是发生了t(2;5)(p23;q25)染色体易位,产生了由间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)与核磷蛋白(nucleophosmin,NPM)胞内结构域的融合基因,高表达的ALK-NPM蛋白是发生间变性淋巴瘤、炎性肌纤维细胞瘤和非小细胞肺癌
[Abstract]:Background there is a tumor called anaplastic large cell lymphoma (ALCL), a rare non-Hodgkin 's T-cell lymphoma, which occurs mostly in skin, bone, soft tissue and multiple organs. The translocation of t _ (2) (p23) Q _ (25) chromosome resulted in the fusion gene from anaplastic lymphoma kinase (anaplastic lymphoma kinase,ALK) and nuclear phosphoprotein (nucleophosmin,NPM) domain. The highly expressed ALK-NPM protein was associated with anaplastic lymphoma, inflammatory myofibrocytoma and non-small cell lung cancer.
【作者单位】： 中国医学科学院、北京协和医学院药物研究所;
【分类号】：R979.1
本文编号：2285002
[Abstract]:Background there is a tumor called anaplastic large cell lymphoma (ALCL), a rare non-Hodgkin 's T-cell lymphoma, which occurs mostly in skin, bone, soft tissue and multiple organs. The translocation of t _ (2) (p23) Q _ (25) chromosome resulted in the fusion gene from anaplastic lymphoma kinase (anaplastic lymphoma kinase,ALK) and nuclear phosphoprotein (nucleophosmin,NPM) domain. The highly expressed ALK-NPM protein was associated with anaplastic lymphoma, inflammatory myofibrocytoma and non-small cell lung cancer.
【作者单位】： 中国医学科学院、北京协和医学院药物研究所;
【分类号】：R979.1
【相似文献】
相关期刊论文 前2条
1 黄海长,杨敏,李惊子,王海燕;结缔组织生长因子通过活化Erk-1/2信号通路促成肌纤维细胞生成[J];中华医学杂志;2005年19期
2 ;[J];;年期
相关会议论文 前1条
1 文佳;葛素云;罗海玲;岳度兵;靳晓霞;许旭;闫乐艳;刘昆;袁飞;;日粮维生素E水平对羊肌纤维细胞膜和线粒体抗氧化性的影响[A];中国畜牧兽医学会养羊学分会全国养羊生产与学术研讨会议论文集[C];2010年
，本文编号：2285002
本文链接：https://www.wllwen.com/yixuelunwen/yiyaoxuelunwen/2285002.html
最近更新
教材专著
