染料木素固体分散体的制备及体外评价
发布时间：2018-10-21 20:46
【摘要】：以聚乙烯吡咯烷酮(PVP K30)为载体,利用喷雾干燥法制备染料木素(1)的固体分散体。采用X射线粉末衍射(XRPD)、差示扫描量热分析(DSC)和激光粒度分析(LD-PSD)对制品进行表征。结果表明,1在固体分散体中均以无定形或分子状态存在。所制备的1-PVP K30(1∶5,w/w)固体分散体平均粒径为(8.9±1.1)?m,在pH 6.8缓冲液中不但可显著提高1的溶解度至8.37 mg/ml,而且可使1在2 h内完全溶出;此外,在25℃/相对湿度60%条件下放置2个月,物理和化学稳定性较好。
[Abstract]:Using polyvinylpyrrolidone (PVP K30) as carrier, the solid dispersion of genistein (1) was prepared by spray drying method. X-ray powder diffraction (XRD) (XRPD), differential scanning calorimetry (DSC) and laser particle size analysis (LD-PSD) were used to characterize the product. The results show that 1 exists in amorphous or molecular state in solid dispersion. The prepared 1-PVP K30 (1: 5 W / w) solid dispersion has an average particle size of (8.9 卤1.1)? m.The solubility of 1 in pH 6.8 buffer solution can be significantly increased to 8.37 mg/ml, and 1 can be completely dissolved in 2 h. In addition, at 25 鈩，
本文编号：2286330
[Abstract]:Using polyvinylpyrrolidone (PVP K30) as carrier, the solid dispersion of genistein (1) was prepared by spray drying method. X-ray powder diffraction (XRD) (XRPD), differential scanning calorimetry (DSC) and laser particle size analysis (LD-PSD) were used to characterize the product. The results show that 1 exists in amorphous or molecular state in solid dispersion. The prepared 1-PVP K30 (1: 5 W / w) solid dispersion has an average particle size of (8.9 卤1.1)? m.The solubility of 1 in pH 6.8 buffer solution can be significantly increased to 8.37 mg/ml, and 1 can be completely dissolved in 2 h. In addition, at 25 鈩，
本文编号：2286330
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