不同材质输液器对丁苯酞氯化钠注射液的吸附性考察

发布时间：2018-11-02 07:18

【摘要】：目的考察丁苯酞专用输液器、聚氯乙烯(PVC)输液器及聚烯烃热塑弹性体(TPE)输液器对丁苯酞氯化钠注射液的吸附性。方法将丁苯酞配成临床用输注浓度,模拟临床静脉滴注,分别经丁苯酞专用输液器、PVC输液器及TPE输液器流出,在不同时间段收集流出的样品,用高效液相色谱法测定丁苯酞浓度,并分别与流经输液器前(0 min)的结果进行比较。结果在总收集液中,丁苯酞专用输液器、PVC输液器及TPE输液器对丁苯酞的吸附率分别为0.47%,32.48%,9.62%;相同材质不同厂家生产输液器对丁苯酞的吸附作用比较,差异均无统计学意义(P0.05)。结论不同材质输液器对丁苯酞的吸附作用有差异,其中PVC输液器对丁苯酞有明显吸附作用;而相同材质不同厂家生产的输液器对丁苯酞的吸附作用无显著差异。
[Abstract]:Objective to investigate the absorbability of butyrophthalide sodium chloride injection with a special infusion device, a polyvinyl chloride (PVC) infusion apparatus and a polyolefin thermoplastic elastomer (TPE) infusion apparatus. Methods Butylphthalide was prepared into clinical infusion concentration, and then simulated by clinical intravenous drip. The samples were collected at different time intervals through butyrophthalide special infusion device, PVC infusion device and TPE infusion device, respectively. The concentration of butylphthalide was determined by high performance liquid chromatography (HPLC), and the results were compared with those before transfusion (0 min). Results in the total collection solution, the adsorption rates of butyrophthalide, PVC infusion and TPE infusion were 0.47 ~ 32.48 and 9.62, respectively. There was no significant difference in the adsorption of butylphthalide between the same materials and different manufacturers (P0.05). Conclusion the adsorption of butylphthalide was different in different infusion devices, among which butyphthalide was adsorbed obviously by PVC infusion device, but there was no significant difference on butyphthalide adsorbed by infusion apparatus produced by different manufacturers of the same material.
【作者单位】：大城县医院创伤科;河北医科大学第二医院药学部;
【分类号】：R971

【相似文献】