光叶巴豆和黄曲霉的化学成分研究
发布时间：2018-11-04 10:49
【摘要】：大戟科(Euphorbiaceae)巴豆属(Croton L.)植物,多为乔木或灌木,稀有草本植物。全世界有800余种,广泛分布于热带、亚热带地区。我国有21种,主要产于台湾、福建(厦门)、广东、海南、广西、云南各省。巴豆属多种植物的枝、叶、皮、根均可入药,其味辛、性热、大毒,用于治疗阻滞肠胃、寒邪食积、卒然腹满胀痛、大便不通、气急口噤等。国内外学者对巴豆属植物的次生代谢产物的研究表明该属植物富含结构多样的二萜类化合物,二萜类化合物也是巴豆属植物的主要活性成分,具有抗肿瘤、抗HIV、抗病原微生物、抗氧化、抗炎镇痛以及降糖等作用。光叶巴豆(Crotolaevigatus)为大戟科巴豆属植物,其化学成分和生物活性报道的很少。曲霉属(Aspergillus)真菌是自然界中分布较普遍的腐生菌之一,曲霉可以产生大量的孢子和具有多种多样的生物化学活性,有些菌种适宜高温或者高的渗透压,使他们能在不同的环境和基物上生长。曲霉属的很多次级代谢产物具有抗生素活性。黄曲霉(Aspergillusfavus)属于曲霉属的真菌。黄曲霉代谢的黄曲霉素也是很好的抗真菌化合物。为了进一步寻找结构新颖或者活性较好的化合物,对光叶巴豆(Croton laevigiatus)和黄曲霉(Aspergillus flavus)的次级代谢产物进行了研究。采用硅胶柱层析(CC)、葡聚糖凝胶柱层析(Sephadex LH-20)、MCI凝胶柱层析、制备薄层色谱法和固液萃取等方法分离得到了 36个化合物;利用EI-MS、HRESIMS、1D NMR(1H NMR、13C NMR、DEPT)、2D NMR(1H-1H COSY、HSQC、HMBC、NOESY)等现代波谱技术,并且结合跟文献数据对比的方法确定了 36个化合物的结构,其中有1个来自光叶巴豆的新化合物。论文最后对1990年以来的巴豆属植物成分和活性进行了综述。
[Abstract]:(Croton L.) of (Euphorbiaceae) genus Euphorbiaceae Plants, mostly trees or shrubs, rare herbs. There are more than 800 species in the world, widely distributed in the tropics, subtropical regions. There are 21 species in China, mainly in Taiwan, Fujian (Xiamen), Guangdong, Hainan, Guangxi, Yunnan provinces. The branches, leaves, skins and roots of many species of the genus Croton can be used in medicine, its flavor, heat, poison, used for the treatment of stomach block, cold evil food accumulation, sudden abdominal distending pain, feces impassability, breath shiver and so on. Studies on secondary metabolites of Croton plants at home and abroad show that the plants are rich in various diterpenoids, and diterpenoids are also the main active components of Croton, which have anti-tumor and anti-HIV,. Anti-pathogenic microorganisms, anti-oxidation, anti-inflammatory, analgesic and hypoglycemic effects. (Crotolaevigatus) is a plant of the genus Croton of Euphorbiaceae, and its chemical composition and biological activity are seldom reported. Aspergillus (Aspergillus) is one of the most common fungi in nature. Aspergillus can produce a large number of spores and have a variety of biochemical activities. Some species are suitable for high temperature or high osmotic pressure. So that they can grow in different environments and substrates. Many secondary metabolites of Aspergillus have antibiotic activity. Aspergillus flavus (Aspergillusfavus) belongs to the genus Aspergillus. Aflatoxin metabolized by Aspergillus flavus is also a good antifungal compound. The secondary metabolites of (Croton laevigiatus) and Aspergillus flavus (Aspergillus flavus) were studied in order to find the compounds with novel structure or good activity. 36 compounds were isolated by silica gel column chromatography, (CC), dextran gel column chromatography (Sephadex LH-20), MCI gel column chromatography), thin layer chromatography and solid-liquid extraction. The structures of 36 compounds were determined by using EI-MS,HRESIMS,1D NMR (1H NMR,13C NMR,DEPT), 2D NMR (1H-1H COSY,HSQC,HMBC,NOESY) and other modern spectral techniques. One of them is a new compound from Paeonia lanceolata. In the end, the composition and activity of Croton since 1990 were reviewed.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R915
本文编号：2309593
[Abstract]:(Croton L.) of (Euphorbiaceae) genus Euphorbiaceae Plants, mostly trees or shrubs, rare herbs. There are more than 800 species in the world, widely distributed in the tropics, subtropical regions. There are 21 species in China, mainly in Taiwan, Fujian (Xiamen), Guangdong, Hainan, Guangxi, Yunnan provinces. The branches, leaves, skins and roots of many species of the genus Croton can be used in medicine, its flavor, heat, poison, used for the treatment of stomach block, cold evil food accumulation, sudden abdominal distending pain, feces impassability, breath shiver and so on. Studies on secondary metabolites of Croton plants at home and abroad show that the plants are rich in various diterpenoids, and diterpenoids are also the main active components of Croton, which have anti-tumor and anti-HIV,. Anti-pathogenic microorganisms, anti-oxidation, anti-inflammatory, analgesic and hypoglycemic effects. (Crotolaevigatus) is a plant of the genus Croton of Euphorbiaceae, and its chemical composition and biological activity are seldom reported. Aspergillus (Aspergillus) is one of the most common fungi in nature. Aspergillus can produce a large number of spores and have a variety of biochemical activities. Some species are suitable for high temperature or high osmotic pressure. So that they can grow in different environments and substrates. Many secondary metabolites of Aspergillus have antibiotic activity. Aspergillus flavus (Aspergillusfavus) belongs to the genus Aspergillus. Aflatoxin metabolized by Aspergillus flavus is also a good antifungal compound. The secondary metabolites of (Croton laevigiatus) and Aspergillus flavus (Aspergillus flavus) were studied in order to find the compounds with novel structure or good activity. 36 compounds were isolated by silica gel column chromatography, (CC), dextran gel column chromatography (Sephadex LH-20), MCI gel column chromatography), thin layer chromatography and solid-liquid extraction. The structures of 36 compounds were determined by using EI-MS,HRESIMS,1D NMR (1H NMR,13C NMR,DEPT), 2D NMR (1H-1H COSY,HSQC,HMBC,NOESY) and other modern spectral techniques. One of them is a new compound from Paeonia lanceolata. In the end, the composition and activity of Croton since 1990 were reviewed.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R915
【参考文献】
相关期刊论文 前8条
1 黄远帆;李小霞;陈国栋;高昊;郭良栋;姚新生;;一株曲霉属地衣内生真菌中新的二苯醚类成分[J];菌物学报;2012年05期
2 胡林峰;韩会娟;朱红霞;王丹;;巴豆提取物抑菌活性初步研究[J];湖南农业科学;2011年07期
3 赵云飞;;巴豆属植物的化学成分、药理作用及临床应用概述[J];贵州畜牧兽医;2008年04期
4 陈伟;李子燕;羊晓东;赵静峰;杨靖华;李良;;银叶巴豆的化学成分研究[J];云南大学学报(自然科学版);2006年03期
5 王媛;邹忠梅;丛浦珠;;巴豆属植物中二萜类成分研究概况[J];国际中医中药杂志;2006年01期
6 吴新安,赵毅民;巴豆属植物化学成分及药理作用研究进展[J];天然产物研究与开发;2004年05期
7 许文林,黄一波,钱俊红,沙鸥;结晶法分离精制混合植物甾醇中β-谷甾醇和豆甾醇[J];过程工程学报;2003年01期
8 孔令义,闵知大,史剑侠,冯锐;麻疯树根的化学成分研究[J];植物学报;1996年02期
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