颅脑手术患者预防性应用抗菌药物临床药师预审的作用探讨

发布时间：2018-11-05 18:43

【摘要】：目的对比分析医院颅脑清洁手术围术期预防使用抗菌药物的情况,探讨制度干预、临床药师预审干预对提高合理用药的可行性。方法选取2010年1月-2015年12月医院神经外科清洁切口手术病历1 323例,对围手术期抗菌药物的选择、给药时间、用法用量和疗程按照年份、季度进行回顾性分析。结果六年间抗菌药物的正确选用率、给药时间的正确率、用法用量正确使用率均呈逐年升高趋势,用药疗程呈逐年缩短趋势,2012年与2013年数据比较差异有统计学意义(P0.05),用法用量正确率在2013年有所波动;药物选择正确率在2010年第二、三季度有短暂升高,从2011年第三季度开始逐渐升高,至2012年第三季度达到最高值;从2012年开始给药时间正确率升高较2011年同期有显著性差异(P0.05);从2011年第三季度开始用法用量正确率逐渐升高,但在2012年第四季度到2013年第三季度有所降低;2011年第三、四季度与2012年第三季度以后的抗菌药物使用疗程较实行干预前有显著性差异(P0.05)。结论临床药师预审和严格的抗菌药物管理制度可极大地促进围手术期抗菌药物的合理使用。
[Abstract]:Objective to compare and analyze the prevention and use of antimicrobial drugs in the perioperative period of craniocerebral cleaning operation in hospital, and to explore the feasibility of system intervention and clinical pharmacist pre-examination intervention to improve the rational use of antibiotics. Methods from January 2010 to December 2015, 1 323 cases of surgical records of neurosurgical clean incision were selected. The choice of antibiotics, the time of administration, the dosage of administration and the course of treatment were analyzed retrospectively according to year and season. Results the correct selection rate of antimicrobial agents, the correct rate of administration time, the correct usage rate of usage of antimicrobial agents increased year by year, and the course of treatment was shortened year by year. The difference between 2012 and 2013 was statistically significant (P0.05), and the correct usage rate fluctuated in 2013. The drug selection accuracy rate rose briefly in the second quarter of 2010 and in the third quarter, rising gradually from the third quarter of 2011 to the highest level in the third quarter of 2012. Compared with the same period of 2011, the correct rate of usage increased gradually from the third quarter of 2011, but decreased from the fourth quarter of 2012 to the third quarter of 2013. In the third and fourth quarter of 2011 and after the third quarter of 2012, there was a significant difference in the course of antimicrobial drug use than before intervention (P0.05). Conclusion Pre-examination of clinical pharmacists and strict antimicrobial management system can greatly promote the rational use of antimicrobial agents in perioperative period.
【作者单位】：连云港市第一人民医院临床药学中心;
【分类号】：R95

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