对强心苷类临床应用相关问题的思考
发布时间：2018-11-09 14:30
【摘要】：强心苷类药物的主要药理机制是抑制心肌细胞膜Na~+-K~+-ATP酶,干扰膜内外相应离子浓度,影响细胞生理功能,致Na~+-Ca~(2+)代偿性交换增多,使心肌收缩性增强并表现相应临床效应。但膜电位的减低使心肌细胞兴奋性增高及传导性下降,为心肌电紊乱提供了可能,也为其临床应用带来诸多争议。特别是当电解质紊乱和心律失常时,对该药的选择和使用存在较多疑点,而对该类药物药理机制和心肌电生理的正确认识和理解是临床安全合理用药的保证。
[Abstract]:The main pharmacological mechanism of cardioside drugs is to inhibit Na~ K- ATP enzyme of myocardial cell membrane, interfere with the corresponding ion concentration inside and outside the membrane, affect the physiological function of cells, and increase the compensatory exchange of Na~ Ca~ (2). The myocardial contractility was enhanced and the corresponding clinical effect was demonstrated. However, the decrease of membrane potential leads to the increase of excitability and the decrease of conduction of myocardial cells, which provides the possibility of myocardial electrical disturbance and brings many controversies to its clinical application. Especially when the electrolyte is in disorder and arrhythmia, there are many doubts about the choice and use of the drug, and the correct understanding and understanding of the pharmacological mechanism and myocardial electrophysiology is the guarantee of safe and reasonable drug use in clinic.
【作者单位】： 陕西省咸阳市第一人民医院;
【分类号】：R972
本文编号：2320684
[Abstract]:The main pharmacological mechanism of cardioside drugs is to inhibit Na~ K- ATP enzyme of myocardial cell membrane, interfere with the corresponding ion concentration inside and outside the membrane, affect the physiological function of cells, and increase the compensatory exchange of Na~ Ca~ (2). The myocardial contractility was enhanced and the corresponding clinical effect was demonstrated. However, the decrease of membrane potential leads to the increase of excitability and the decrease of conduction of myocardial cells, which provides the possibility of myocardial electrical disturbance and brings many controversies to its clinical application. Especially when the electrolyte is in disorder and arrhythmia, there are many doubts about the choice and use of the drug, and the correct understanding and understanding of the pharmacological mechanism and myocardial electrophysiology is the guarantee of safe and reasonable drug use in clinic.
【作者单位】： 陕西省咸阳市第一人民医院;
【分类号】：R972
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