正青霉属真菌次生代谢产物的研究进展

发布时间：2018-11-11 22:02

【摘要】：正青霉属(Eupenicillium)真菌作为有性型青霉属的重要分支之一,种类多样,目前已收载了62种。研究发现,该属真菌的次生代谢产物种类多样,具有丰富的化学多样性。本文从菌株来源、化合物结构及其生物活性等方面,综述了自1974年第一个正青霉属真菌天然产物到2016年9月已报道的共66个正青霉属真菌来源的重要天然产物,且50%的化合物表现出细胞毒、抑菌、抗氧化和抗寄生虫等生物活性,为药物的研发提供了潜在的先导化合物,具有很好的研究及药用开发价值。
[Abstract]:As one of the important branches of the genus Penicillium, Penicillium (Eupenicillium) has 62 species. It was found that the secondary metabolites of this genus were diverse in species and abundant in chemical diversity. In this paper, the important natural products from 66 natural products of Penicillium from the first natural product of Penicillium in 1974 to the reported in September 2016 were reviewed from the source of strain, structure of compounds and their biological activity. Moreover, 50% of the compounds showed biological activities such as cytotoxicity, bacteriostatic, antioxidation and anti-parasite, which provided potential leading compounds for drug research and development.
【作者单位】： 江西科技师范大学生命科学学院江西省生物加工过程重点实验室;江西师范大学生命科学学院江西省亚热带植物资源保护与利用重点实验室;
【基金】：国家自然科学基金(31260137,81260617,31300051) 赣鄱英才555工程”领军人才计划 江西科技师范大学研究生创新专项资金(YC2015-X11)
【分类号】：R915
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本文编号：2326267