聚四氟乙烯微针模具的性能考察

发布时间：2018-11-18 14:55

【摘要】：目的:考察用聚四氟乙烯(PTFE)制作相转化水凝胶微针模具的性能。方法:聚四氟乙烯模具经过粉末的过筛、压制、烧结、制孔而得。实验制备了不同聚四氟乙烯粉料粒度、不聚四氟乙烯粉料用料量、不同生料板压制压力的聚四氟乙烯微针模具,向模具中浇注以PVA为基质的聚合物溶液,通过冷冻解冻制得相转化水凝胶微针,考察模具的孔径、载料量以及微针的揭膜难易程度和完形率。结果:80目以上细度的模具透光性能均一;随着聚四氟乙烯用料量的增加和生料板压制压力的增大,模具的孔径和载药量减小,揭膜更容易、完形率更高。结论:聚四氟乙烯模具的性能与其密度密切相关,密度越大的模具,蠕变的随意性越大,因而孔洞均一性下降,但是揭膜性能变好,完形率提高。这两个相反的趋势提示我们,四氟乙烯模具的优劣是相转化水凝胶微针中的第一个控制性因素,聚四氟乙烯是制作微针模具的可接受材料,有进一步研究的价值。
[Abstract]:Objective: to investigate the properties of phase-transformed hydrogel micro-needle mould made of PTFE (PTFE). Methods: PTFE mould was obtained by powder screening, compaction, sintering and pore making. The polytetrafluoroethylene microneedle mould with different size of PTFE powder, no amount of PTFE powder, different pressing pressure of raw material board was prepared, and the polymer solution based on PVA was poured into the mould. Phase converted hydrogel microneedles were prepared by freezing and thawing, and the pore size, loading capacity, ease of uncovering film and cloze rate of microneedles were investigated. Results: with the increase of PTFE and the pressing pressure of raw material, the diameters and drug loading of the mould decreased, the film uncovering was easier, and the gestation rate was higher. Conclusion: the properties of PTFE dies are closely related to their densities. The higher the density, the greater the randomness of creep, thus the homogeneity of voids decreases, but the film uncovering performance becomes better and the cloze rate increases. These two opposite trends suggest that the advantages and disadvantages of tetrafluoroethylene mould are the first controlling factor in the phase conversion hydrogel microneedle and PTFE is an acceptable material for the fabrication of microneedle mould which has the value of further study.
【作者单位】：上海交通大学药学院;
【基金】：国家自然科学基金项目(81173001)
【分类号】：R944

【相似文献】