碘化钾微乳的制备及其体外透皮吸收作用考察

发布时间：2018-11-23 17:50

【摘要】：目的:制备碘化钾微乳并考察其透皮吸收的效果。方法:以伪三元相图为基础,依据微乳区域大小,确定微乳的油相、乳化剂、助乳化剂和后二者的比例(Km),初步筛选微乳处方;采用改进的Franz扩散池和离体小鼠皮肤进行体外经皮渗透试验,比较所制5%、10%碘化钾微乳与5%碘化钾溶液单位面积的累积渗透量(Qn),并对微乳进行加速稳定性试验。结果:碘化钾微乳的最优处方为碘化钾10%(m/V)、水23%、混合乳化剂(月桂山梨坦-乙醇Km值为1∶1)61.6%、油相(丙二醇单辛酸酯)15.4%;所制微乳的渗透过程符合一级速率方程,3种样品的Q24 h分别为(5.40±0.28)、(8.75±0.42)、(2.12±0.20)mg/cm2;40℃下贮存4周后所制微乳与贮存前比较p H、含量、外观均未见明显变化。结论:成功制得具有透皮吸收作用的碘化钾微乳。
[Abstract]:Objective: to prepare potassium iodide microemulsion and evaluate its transdermal absorption. Methods: on the basis of pseudo-ternary phase diagram and according to the size of microemulsion, the oil phase, emulsifier, assistant emulsifier and the ratio of co-emulsifier and the latter were determined by (Km),. The modified Franz diffusion cell and mouse skin were used for in vitro percutaneous osmotic test. The cumulative permeation capacity (Qn),) of 10% potassium iodide microemulsion and 5% potassium iodide solution per unit area was compared and the accelerated stability test of the microemulsion was carried out. Results: the optimum formulation of potassium iodide microemulsion was 10% (m / V) of potassium iodide, 23% water, 61.6% mixed emulsifier (Km = 1:1) and 15.4% oil phase (propylene glycol monooctanoate). The osmotic process of the prepared microemulsion was in accordance with the first-order rate equation. The Q24 h of the three samples was (5.40 卤0.28), (8.75 卤0.42), (2.12 卤0.20) mg/cm2;, respectively. After storage at 40 鈩，

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