盐酸特比萘芬药物制剂的研究进展

发布时间：2018-11-24 17:32

【摘要】：目的:为盐酸特比萘芬新剂型、经皮给药制剂的研发提供参考。方法:以"特比萘芬""醇质体""纳米乳""Terbinafine hydrochloride"等为关键词,组合检索1995年1月-2015年8月在中国知网中收录的盐酸特比萘芬文献,综述其疗效研究、药动学研究、临床常用剂型以及新剂型、新载药体制备工艺的研究前景和方向。结果:共查阅到相关文献2 769篇,其中有效文献26篇。盐酸特比萘芬抗真菌机制明确,抗真菌谱广,疗效确切;近年临床上作为一线抗真菌皮肤病用药,药动学研究文献详实;临床常用剂型多而各有用药特点;新剂型、新载药制备工艺较少,主要有纳米乳、固体脂质纳米粒、β-环糊精包合物、二元醇质体等。结论:现代载药制备工艺的不断深入研究和不断创新,为制备高效低毒新剂型、经皮给药制剂打下了坚实的基础。
[Abstract]:Objective: to provide a reference for the development of a new formulation of terbinafine hydrochloride and transdermal drug delivery. Methods: the terbinafine hydrochloride literature collected from January 1995 to August 2015 was searched for the terbinafine hydrochloride literature from January 1995 to August 2015. The therapeutic effect and pharmacokinetics of terbinafine hydrochloride were reviewed. The research prospect and direction of clinical commonly used dosage form, new dosage form and new drug carrier preparation technology. Results: a total of 2769 articles were reviewed, of which 26 were valid. The antifungal mechanism of terbinafine hydrochloride is clear, the antifungal spectrum is wide and the curative effect is definite. In recent years, the pharmacokinetics of terbinafine hydrochloride as a first-line antifungal dermatosis drug is well documented. New dosage form, new drug carrier preparation technology is less, mainly has nanometer emulsion, solid lipid nanoparticles, 尾 -cyclodextrin inclusion complex, diol plastids and so on. Conclusion: the further study and innovation of the modern preparation technology of drug loading have laid a solid foundation for the preparation of new formulations of high efficiency and low toxicity and transdermal drug delivery.
【作者单位】：长春医学高等专科学校药学系药剂教研室;
【分类号】：R943

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