我院老年患者使用利奈唑胺的不良反应分析

发布时间：2018-11-24 18:14

【摘要】：目的:对老年住院患者使用利奈唑胺的安全性进行分析,并探讨其不良反应发生规律。方法:采用回顾性研究方法,选取我院2014年1月-2015年12月使用利奈唑胺注射剂或片剂的老年患者病例,统计并分析不良反应发生情况。结果:共纳入有效病例126例,年龄65~94岁,使用利奈唑胺的平均时间为(9.47±6.31)d(范围1~35 d)。用药后出现不良反应的有45例(35.71%),其中血小板减少39例(30.95%),白细胞减少9例(7.14%),血红蛋白减少7例(5.55%),恶心、呕吐6例(4.76%),转氨酶升高4例(3.17%),腹泻4例(3.17%),乳酸性酸中毒2例(1.59%),皮疹2例(1.59%),药物热1例(0.79%)。重症监护治疗病房(ICU)患者血小板减少症的发生率明显高于非ICU患者,差异有统计学意义(P=0.019);利奈唑胺不同剂型间的发生率比较,差异无统计学意义(P=0.218)。结论:医师和临床药师应该对使用利奈唑胺的老年患者密切监护,警惕不良反应的发生,尤其是ICU患者,其血小板减少发生率较高,且应常规监测血清乳酸水平。
[Abstract]:Objective: to analyze the safety and the occurrence of adverse reactions in elderly inpatients. Methods: retrospective study was used to analyze the incidence of adverse reactions in elderly patients who were treated with linazolamide injection or tablet from January 2014 to December 2015 in our hospital. Results: a total of 126 effective cases, aged 65 to 94 years, were included. The average time of using linazolamide in the range of (9.47 卤6.31) d () was (9.47 卤6.31) d () for 35 d). There were 45 cases (35.71%) with adverse reactions, including 39 cases of thrombocytopenia (30.95%), 9 cases of leukopenia (7.14%) and 7 cases of hemoglobin decrease (5.55%). There were 6 cases of vomiting (4.76%), 4 cases of elevated aminotransferase (3.17%), 4 cases of diarrhea (3.17%), 2 cases of acid acidosis (1.59%), 2 cases of rash (1.59%), 1 case of drug fever (0.79%). The incidence of thrombocytopenia in (ICU) patients in intensive care unit was significantly higher than that in non-ICU patients (P0. 019), but there was no significant difference between different dosage forms of linazolamine (P0. 218). Conclusion: physicians and clinical pharmacists should closely monitor the elderly patients with linazolamide use and be alert to the occurrence of adverse reactions, especially in patients with ICU, the incidence of thrombocytopenia is high, and the level of serum lactic acid should be routinely monitored.
【作者单位】：中山大学附属第一医院药学部;中山大学药学院;中山大学中山医学院药理学教研室;
【分类号】：R978.1;;R969.3

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