盐酸布替萘芬微乳温敏凝胶的制备及质量评价

发布时间：2018-11-26 19:06

【摘要】：目的制备盐酸布替萘芬微乳温敏凝胶,并对其质量进行评价。方法以油酸乙酯为油相,聚山梨酯80为乳化剂,无水乙醇为助乳化剂,泊洛沙姆188和407为温敏材料,制备对体表温度敏感的微乳凝胶,并对其形态、粒径、稳定性进行考察,和市售乳膏进行透皮吸收速度和皮内滞留量的对比。结果微乳凝胶最终处方为:油酸乙酯-聚山梨酯80-无水乙醇-P407-P188-纯化水=4∶15∶10∶16.33∶5.68∶71。所得的微乳为水包油型,透射电镜下乳滴呈圆球形,平均粒径91.03 nm,PDI为0.246,自制微乳凝胶透皮速度较市售乳膏快,皮肤内药物滞留量为市售乳膏的5倍。结论该实验制备得到的温敏微乳凝胶具有良好的温度敏感性和透皮滞留效果,能够以较快速度进入皮肤内层形成药物贮库,提高局部药物浓度,增强抗菌效果。
[Abstract]:Objective to prepare and evaluate the temperature sensitive gel of butenafine hydrochloride microemulsion. Methods using ethyl oleate as oil phase, polysorbate 80 as emulsifier, anhydrous ethanol as co-emulsifier, Poloxamer 188 and 407 as temperature-sensitive materials, microemulsion gel sensitive to body surface temperature was prepared, and its morphology, particle size and stability were investigated. The rate of transdermal absorption and the amount of intradermal retention were compared with those of market cream. Results the final formulation of microemulsion gel was as follows: ethyl oleate-polysorbate 80-anhydrous ethanol-P407-P188- purified water = 4: 15: 10: 16.33: 5.68: 71. The microemulsion was oil-in-water, and the emulsion droplets were spherical under transmission electron microscope (TEM). The average particle size was 91.03 nm,PDI (0.246). The transdermal speed of self-made microemulsion gel was faster than that of commercial cream, and the drug retention in skin was 5 times of that of marketed cream. Conclusion the prepared thermo-sensitive microemulsion gel has good temperature sensitivity and transdermal retention effect. It can enter the skin inner layer quickly to form a drug reservoir, increase the local drug concentration and enhance the antimicrobial effect.
【作者单位】：济宁医学院药学院;济南大学山东省医学科学院医学与生命科学学院;
【基金】：济宁医学院2013年度校级科研计划项目(JY2013KJ012) 地方高校国家级大学生创新创业训练计划项目(201610443020) 济宁医学院大学生创新训练计划项目(cx2016020)
【分类号】：R943

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