顶空气相色谱法测定帕利哌酮中的溶剂残留量

发布时间：2018-11-28 13:54

【摘要】：目的建立顶空毛细管柱气相色谱法测定帕利哌酮中的溶剂残留量。方法以Agilent DB-624(30 m×530μm,3μm)柱为色谱柱,以氮气为载气,以氢火焰离子化检测器检测,以N,N-二甲基乙酰胺为溶剂,采用程序升温模式检测帕利哌酮原料药中甲醇、乙酸乙酯、二氯甲烷和三乙胺的残留量。结果 4种挥发性有机溶剂均达到基线分离,在考察的质量浓度内线性良好(r≥0.999 0),平均回收率分别为103.1%、101.9%、101.3%和100.8%,RSD分别为2.9%、2.8%、3.3%和6.2%(n=9)。结论该方法操作简单、快速、灵敏、可靠,可用于帕利哌酮原料药中4种有机溶剂残留量测定。
[Abstract]:Objective to establish a headspace capillary gas chromatographic method for the determination of solvent residues in peridol. Methods Agilent DB-624 (30 m 脳 530 渭 m) column was used as chromatographic column, nitrogen as carrier gas, hydrogen flame ionization detector as detector, Nn- dimethyl acetamide as solvent, and temperature programmed mode for the determination of methanol in parpiperidone raw drug. Residues of ethyl acetate, dichloromethane and triethylamine. Results all of the four volatile organic solvents reached the baseline separation. The internal linearity of the four volatile organic solvents was good (r 鈮，

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