聚乙二醇化脂质体引起的加速血液清除现象研究进展

发布时间：2018-12-06 20:54

【摘要】：目的:为聚乙二醇(PEG)化脂质体的研究和应用提供参考。方法:以"PEG""Accelerated blood clearance phenomenon""加速血液清除"等为关键词,组合查询1987-2013年在Pub Med、Elsevier Science Direct、维普数据库中相关文献,就PEG化脂质体引起的加速血液清除现象(ABC现象)的产生原因和影响因素进行归纳与总结。结果与结论:共查询到83条文献,其中有效文献37条。经分析文献发现,注射剂量、PEG的量和PEG链的长度、粒径和表面电荷、注射时间间隔以及不同动物模型、包裹药物等,均可导致不同程度的ABC现象,建议通过对PEG部分进行修饰、改变聚合物材料、包裹具有免疫抑制作用的药物以及改变注射方式等方法减弱或消除ABC现象。研究表明,对PEG的修饰和寻找PEG的替代品是比较有前途和希望的解决方案,可为日后开发一种没有免疫原性的PEG化脂质体提供一定的理论基础。
[Abstract]:Objective: to provide reference for the study and application of polyethylene glycol (PEG) liposomes. Methods: according to the key words of "PEG", "Accelerated blood clearance phenomenon", "accelerated blood clearance" and so on, the relevant documents in Pub Med,Elsevier Science Direct, Wiper database from 1987 to 2013 were selected. The causes and influencing factors of accelerated blood clearance (ABC) induced by PEG liposomes were summarized and summarized. Results & conclusion: a total of 83 articles were investigated, of which 37 were valid. It was found that injection dose, amount of PEG and length of PEG chain, particle size and surface charge, interval of injection time, different animal models, encapsulation of drugs, etc., could lead to different degrees of ABC phenomenon. It is suggested that the modification of PEG, the modification of polymer materials, the encapsulation of immunosuppressive drugs and the modification of injection methods should be used to weaken or eliminate the phenomenon of ABC. The results show that the modification of PEG and the search of PEG substitute are promising and promising solutions, which can provide a theoretical basis for the future development of a PEG liposome without immunogenicity.
【作者单位】：第四军医大学第一附属医院药剂科;第四军医大学药剂学教研室;
【分类号】：R969.3

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