溴新斯的明多囊脂质体的制备及其体外释放行为的初步研究

发布时间：2018-12-11 12:25

【摘要】：目的:制备溴新斯的明多囊脂质体(NB-MVL),并对其体外药物释放行为进行考察。方法:采用复乳法制备载药多囊脂质体,并用单因素试验优化处方,以动态透析技术与f2相似因子评价法对NB-MVL与溴新斯的明在体外不同释放介质中的释放行为进行研究,计算其药物释放度与相似因子。结果:NB-MVL的包封率受投料比、药物浓度等因素影响;NB-MVL在不同的释放介质中所获得的释放模型均符合Weibull模型,同时与溴新斯的明溶液在不同释放介质中所得累积释放曲线间的相似因子小于50。结论:本试验制备所得NB-MVL包封率较高,且体外药物释放行为与溴新斯的明存在显著性差异,表现出良好的缓释作用。
[Abstract]:Aim: to prepare bromoneostigmine polycystic liposomes (NB-MVL) and investigate their drug release behavior in vitro. Methods: drug loaded polycystic liposomes were prepared by double emulsion method. The release behavior of NB-MVL and bromoxtigmine in different release media in vitro was studied by dynamic dialysis technique and f2 similarity factor evaluation method, and single factor test was used to optimize the formulation. The drug release and similar factors were calculated. Results: the entrapment efficiency of NB-MVL was influenced by the ratio of feed and the concentration of drug. The release models obtained by NB-MVL in different release media all accord with the Weibull model, and the similarity factor between the cumulative release curve and bromoxamine solution in different release media is less than 50. Conclusion: the entrapment efficiency of NB-MVL prepared in this study was high, and the drug release behavior in vitro was significantly different from that of brominostigmine, showing a good sustained release effect.
【作者单位】：重庆医科大学药物高校工程研究中心;重庆医科大学附属第二医院药学部;
【分类号】：R943;R96

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