中国人群CYP4F2基因多态性对华法林维持剂量影响的系统评价
发布时间：2018-12-12 07:35
【摘要】：目的:系统评价中国人群CYP4F2基因多态性与华法林维持剂量的关系,以为临床治疗提供循证参考。方法:计算机检索Cochrane图书馆、Pub Med、EMBase、相关期刊论文、中文科技期刊数据库和万方数据库,收集中国人群CYP4F2基因多态性与华法林维持剂量关系的研究,提取资料并进行质量评价后,采用Rev Man 5.0统计软件进行Meta分析。结果:共纳入13项研究,合计2 958例患者,基因检测结果分为TT、CT和CC型。Meta分析结果显示,CYP4F2的3种基因型华法林稳定剂量的关系为:TT型CT型CC型,各组间比较差异均有统计学意义。结论:中国人群CYP4F2基因多态性与华法林维持剂量有显著相关性。受纳入研究方法学质量的限制,该结论有待大样本、高质量的研究进一步验证。
[Abstract]:Objective: to evaluate the relationship between CYP4F2 gene polymorphism and warfarin maintenance dose in Chinese population, and to provide evidence-based reference for clinical treatment. Methods: Cochrane library, Pub Med,EMBase, full text database, Chinese sci-tech journal database and Wanfang database were searched by computer. The relationship between CYP4F2 gene polymorphism and warfarin maintenance dose was collected. After extracting the data and evaluating the quality, Meta analysis was carried out by Rev Man 5.0 statistical software. Results: a total of 2 958 patients were included in 13 studies. The results of gene detection were divided into TT,CT and CC types. Meta analysis showed that the stable dose relationship of warfarin genotypes of CYP4F2 was TT CT CC. There were significant differences between the groups. Conclusion: there is a significant correlation between CYP4F2 gene polymorphism and warfarin maintenance dose in Chinese population. Limited by the quality of methodology included in the study, this conclusion needs to be further verified by a large sample of high-quality research.
【作者单位】： 杭州市第一人民医院药学部;浙江中医药大学人事处;
【基金】：浙江省药学会医院药学专项科研资助项目(No.2014ZYY18)
【分类号】：R973
[Abstract]:Objective: to evaluate the relationship between CYP4F2 gene polymorphism and warfarin maintenance dose in Chinese population, and to provide evidence-based reference for clinical treatment. Methods: Cochrane library, Pub Med,EMBase, full text database, Chinese sci-tech journal database and Wanfang database were searched by computer. The relationship between CYP4F2 gene polymorphism and warfarin maintenance dose was collected. After extracting the data and evaluating the quality, Meta analysis was carried out by Rev Man 5.0 statistical software. Results: a total of 2 958 patients were included in 13 studies. The results of gene detection were divided into TT,CT and CC types. Meta analysis showed that the stable dose relationship of warfarin genotypes of CYP4F2 was TT CT CC. There were significant differences between the groups. Conclusion: there is a significant correlation between CYP4F2 gene polymorphism and warfarin maintenance dose in Chinese population. Limited by the quality of methodology included in the study, this conclusion needs to be further verified by a large sample of high-quality research.
【作者单位】： 杭州市第一人民医院药学部;浙江中医药大学人事处;
【基金】：浙江省药学会医院药学专项科研资助项目(No.2014ZYY18)
【分类号】：R973
【参考文献】
相关期刊论文 前6条
1 王贞;杨冬;李艳莲;袁百香;袁宏;刘艳;;细胞色素P450酶4F2基因多态性对华法林剂量的影响[J];广东医学;2011年23期
2 罗志方;江美兰;章祖雄;;基因多态性对华法林抗凝治疗维持剂量的影响[J];江西医药;2013年04期
3 王芳芳;郭心灵;李菲菲;郜莉娜;尤崇革;;基于华法林药物基因组学的临床用药模型建立[J];分子诊断与治疗杂志;2012年02期
4 张海燕;罗万慰;方焕荣;杨协清;许联红;马守梅;;VKORC1、CYP2C9、CYP4F2、EPHX1基因多态性对华法林剂量的影响[J];中国药房;2012年34期
5 朱君荣;魏萌;朱余兵;谢渡江;于锋;叶飞;陶宜富;;CYP4F2、CYP2C9和VKORC1基因多态性对中国汉族非瓣膜性房颤患者使用华法林剂量的影响[J];中国药房;2012年44期
6 闻武;黄烽;阳丽梅;韩涛;;CYP2C93,VKORC1-1639G>A和CYP4F2 rs2108622基因多态性对华法林剂量的影响[J];中国胸心血管外科临床杂志;2013年04期
相关硕士学位论文 前2条
1 李R蓟，
本文编号：2374192
本文链接：https://www.wllwen.com/yixuelunwen/yiyaoxuelunwen/2374192.html
最近更新
教材专著
