质子泵抑制剂预防应激性溃疡效果及药物经济学分析

发布时间：2018-12-14 11:47

【摘要】：目的 :分析不同类型质子泵抑制剂(Proton pump inhibitor,PPIs)预防应激性溃疡(Stress ulcer,SU)的临床效果及药物经济学比较。方法 :以我院2008年6月—2015年6月收治的652例接受PPIs预防SU的患者为研究对象,进行回顾性分析。按照患者PPIs药物类型,将其分为奥美拉唑组(n=271)、兰索拉唑组(n=228)及泮托拉唑组(n=153),比较各组患者SU发生率及成本—效果比等指标,探讨最佳的SU预防药物。结果 :奥美拉唑组SU发生率、死亡率显著高于兰索拉唑组、泮托拉唑组,差异有统计学意义(P0.05),兰索拉唑组、泮托拉唑组SU发生率、死亡率比较,差异无统计学意义(P0.05)。各组患者不良反应发生率比较,差异无统计学意义(P0.05)。奥美拉唑组成本—效果比(C/E)最低,兰索拉唑组C/E最高,差异有统计学意义(P0.05)。结论 :PPIs在SU的预防中具有积极作用,其中,奥美拉唑预防SU成本最低,但效果有限,兰索拉唑与泮托拉唑预防SU的效果相仿,而泮托拉唑成本更低,故建议将泮托拉唑作为SU的预防首选药物。
[Abstract]:Aim: to analyze the clinical effect of proton pump inhibitor (Proton pump inhibitor,PPIs) in the prevention of stress ulcer (Stress ulcer,SU) and its pharmacoeconomic comparison. Methods: from June 2008 to June 2015, 652 patients who received PPIs to prevent SU were retrospectively analyzed. According to the drug types of PPIs, the patients were divided into three groups: omeprazole group (n = 271), lansoprazole group (n = 228) and pam Tora group (n = 153). The incidence of SU and the cost-effectiveness ratio were compared to explore the best preventive drugs for SU. Results: the incidence and mortality of SU in omeprazole group were significantly higher than those in lansoprazole group and pansoprazole group (P0.05). The incidence and mortality of SU in lansoprazole group and pam Tora group were significantly higher than those in lansoprazole group and pansoprazole group (P0.05). The difference was not statistically significant (P0.05). There was no significant difference in the incidence of adverse reactions in each group (P0.05). The cost-effect ratio (C / E) of omeprazole group was the lowest, and that of lansoprazole group was the highest (P0.05). Conclusion: PPIs plays an active role in the prevention of SU. The cost of omeprazole is the lowest, but the effect is limited. The effect of lansoprazole and pansoprazole on preventing SU is similar, but the cost of pam Tora is lower. Therefore, it is suggested that pam Tora azole should be the first choice for the prevention of SU.
【作者单位】： 上海杨思医院急诊科;
【分类号】：R975

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