载药系统中的静电纺丝材料及其应用

发布时间：2018-12-16 02:21

【摘要】：背景:近些年来,静电纺丝材料正在临床载药领域得到越来越广泛的应用。目的:综述静电纺丝材料在载药系统中的应用及其前景。方法:以"Electrospinning,drug delivery system,nanofibers,electrospun materials"为关键词,检索Pub Med、NCBI数据库中近10年来关于载药电纺支架在组织工程、肿瘤化疗等临床应用领域的最新进展。结果与结论:与传统材料相比,静电纺丝支架具有良好的多样性及参数高可控性,在针对不同组织生理条件下的个性化应用具有独到优势。目前相关载药材料主要由天然产物、合成高分子材料及混纺材料等构成,搭载药物主要包括抗生素、化疗药、蛋白质及DNA等。静电纺丝材料在临床主要应用于组织工程、肿瘤化疗、创面愈合等领域,如何实现药物在多聚物溶液中的稳定均一扩散的同时保证高载药率及低药物流失是最终的目标。相信电纺材料以其固有优势配合多样化的载药方案,必将在这一交叉学科中获得更大的发展。
[Abstract]:Background: in recent years, electrostatic spinning materials are more and more widely used in the field of drug loading. Objective: to review the application and prospect of electrostatic spinning materials in drug loading system. Methods: using "Electrospinning,drug delivery system,nanofibers,electrospun materials" as the key word, the latest progress in clinical application of drug-loaded electrospinning stents in tissue engineering, tumor chemotherapy and so on was searched in Pub Med,NCBI database in recent 10 years. Results & conclusion: compared with traditional materials, electrostatic spinning scaffold has good diversity and high controllability of parameters, and has unique advantages in individualized application under different tissue physiological conditions. At present, the related drug loading materials are mainly made up of natural products, synthetic polymer materials and blended materials. The carrying drugs mainly include antibiotics, chemotherapeutic drugs, protein, DNA and so on. Electrostatic spinning materials are mainly used in the field of tissue engineering, tumor chemotherapy, wound healing and so on. How to achieve stable and homogeneous diffusion of drugs in polymer solution while ensuring high drug loading rate and low drug loss is the ultimate goal. It is believed that electrospinning materials with their inherent advantages in combination with a variety of drug loading schemes will be further developed in this interdisciplinary discipline.
【作者单位】：上海交通大学医学院附属瑞金医院临床医学院;上海交通大学医学院附属瑞金医院普外科;苏州大学骨科研究所;
【基金】：上海市医务工会“星光计划”优秀(资助)项目(2014年),课题负责人:费健~~
【分类号】：R943

【相似文献】