酒精与药物作用致双硫仑样反应22例分析

发布时间：2018-12-18 11:10

【摘要】：目的探讨酒精与药物所致双硫仑样反应防治。目前临床上应用头孢菌素类,硝咪唑类,硝基呋喃类,磺脲酰类双胍类降血糖药物等期间饮酒致双硫仑样反应较常见,易被误诊误治,临床医师护师应高度重视。方法对本院2012年1月至2015年12月期间由于使用不同类型药物饮酒导致的双硫仑样反应22例进行回顾性分析。结果 (1)双硫仑样反应可出现于各年龄段的患者。(2)双硫仑样反应的药物常见于头孢类抗生素,硝咪唑类抗菌药,硝基呋喃类抗菌药,磺酰脲类双胍类降血糖药物等;(3)症状有面包潮红,胸闷头痛,心悸,气促,烦躁低血压,心绞痛,呼吸困难,恶心呕吐等;(4)除饮用各种酒类还见于服用藿香正气水,酒心巧克力等。(5)双硫仑样反应出现于使用这些药物治疗过程中和治疗结束72小时内。(6)双硫仑样反应出现于饮酒后30分钟内。结论医护人员对双硫仑样反应高度重视,尤其是老年人和心血管疾病患者,避免引起误诊误治。
[Abstract]:Objective to investigate the prevention and treatment of dithiolon-like reaction induced by alcohol and drugs. At present, the use of cephalosporins, niramidazoles, nitrofurans, sulfonylurea biguanidine hypoglycemic drugs and other periods of alcohol drinking is more common, easily misdiagnosed and mistreated, clinicians should pay great attention to. Methods from January 2012 to December 2015, 22 cases of disulfiendron-like reactions caused by drinking with different types of drugs were retrospectively analyzed. Results (1) Dithiolon-like reaction could occur in patients of all ages. (2) Dithiolon-like reactions were common in cephalosporins, niramidazoles, nitrofurans, sulfonylurea biguanidine, and so on. (3) symptoms include flushing bread, chest tightness and headache, palpitations, shortness of breath, irritable hypotension, angina pectoris, dyspnea, nausea and vomiting. (4) in addition to drinking various kinds of alcohol, they are also found in taking patchouli Zhengqi water, (5) Dithiolan-like reaction occurred during the treatment of these drugs and within 72 hours after treatment, (6) the dithiolon-like reaction appeared within 30 minutes after drinking. Conclusion the medical staff attach great importance to the disulfiron-like reaction, especially in the elderly and patients with cardiovascular disease, to avoid misdiagnosis and mistreatment.
【作者单位】：西安冶金医院;
【分类号】：R595.3

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