挤出滚圆过程中挤出物表面粗糙度的表征方法

发布时间：2019-01-07 09:46

【摘要】：在挤出滚圆法制备微丸中,挤出物的特征物理性质直接影响微丸的成型质量,是微丸处方、工艺研究的核心因素。研究表明,挤出物的表面粗糙度是挤出物特征物理性质之一,与微丸成型质量具有重要的相关性。以蒸馏水为润湿剂,以微晶纤维素、白前提取物为原料制备挤出物,采用显微镜获取挤出物图片,以粒度粒形分析仪的软件进行图片分析,建立并确定了基于等效周长椭圆的表面粗糙度表征方程。方法学考察结果表明,本法具有较高的精密度、准确性、灵敏度。进一步采用本法考察润湿剂不同用量下得到的不同挤出物的表面粗糙度,及表面粗糙度与微丸成型性的关联。结果表明,对于不同的原料,挤出物表面粗糙度对微丸成型性的影响不同。
[Abstract]:The characteristic physical properties of extruded pellets directly affect the molding quality of pellets and are the core factors in the preparation of pellets. The results show that the surface roughness of the extruded material is one of the physical properties of the extruded material and has an important correlation with the molding quality of the pellets. The extrudate was prepared by using distilled water as wetting agent, microcrystalline cellulose and prewhite extract as raw material. The extrusion pictures were obtained by microscope, and the image was analyzed by the software of particle size analyzer. The surface roughness representation equation based on the equivalent circumference ellipse is established and determined. The results of methodological investigation show that the method has high precision, accuracy and sensitivity. The relationship between the surface roughness and the molding property of the pellets was investigated by using this method under different contents of wetting agent. The results show that the influence of surface roughness of extruded material on the molding property of pellets is different for different raw materials.
【作者单位】：上海中医药大学中药现代制剂技术教育部工程研究中心;上海张江中药现代制剂技术工程研究中心;
【基金】：国家青年自然科学基金项目(81202923) 上海市卫计委新三年行动计划(ZY3-CCCX-3-5001) 上海市科委项目资助(15DZ2292000)
【分类号】：R94

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